Demographic and clinical characteristics associated with treatment status in family members with obsessive-compulsive disorder

Bernadette Cullen; Jack F Samuels; Anthony Pinto; Abby J Fyer; James T McCracken; Scott L Rauch; Dennis L Murphy; Benjamin D Greenberg; James A Knowles; John Piacentini; O Joseph Bienvenu III; Marco A Grados; Mark A Riddle; Steven A Rasmussen; David L Pauls; Virginia L Willour; Yin Y Shugart; Kung-Yee Liang; Rudolf Hoehn-Saric; Gerald Nestadt

doi:10.1002/da.20293

Journal article

Demographic and clinical characteristics associated with treatment status in family members with obsessive-compulsive disorder

Bernadette Cullen, Jack F Samuels, Anthony Pinto, Abby J Fyer, James T McCracken, Scott L Rauch, Dennis L Murphy, Benjamin D Greenberg, James A Knowles, John Piacentini, …

Depression and anxiety, Vol.25(3), pp.218-224

2008

DOI: 10.1002/da.20293

PMID: 17345603

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Abstract

This study investigated the demographic and clinical factors that influence treatment status in family members with obsessive compulsive disorder (OCD). Six hundred and two subjects from the OCD Collaborative Genetics Study were interviewed using the Structured Clinical Interview for DSM-IV (SCID) to diagnose Axis I disorders, and the Yale-Brown Obsessive Compulsive Scale (Y-BOCS) for assessment of OCD symptoms. The demographic and clinical data were compared between subjects who had received treatment and those who had not. A precipitous onset of symptoms, severe illness, multiple obsessions and compulsions, and co-morbid affective disorders were all positively associated with receiving treatment. Older age and the presence of obsessive compulsive personality disorder (OCPD) or OCPD traits were negatively associated with treatment. Gender and age at onset of symptoms did not predict treatment history. The mean duration from onset of symptoms to receiving treatment was 13.8+/-SD 11.9 years, but there was a direct relationship between current age and time to treatment, with younger subjects receiving treatment sooner. Clinical factors are predominant in predicting treatment status in family members with OCD. Although the mean duration from onset of symptoms to treatment was long, younger family members appear to receive treatment sooner.

Comorbidity

Diagnostic and Statistical Manual of Mental Disorders

Age Factors

Attitude to Health

Obsessive-Compulsive Disorder - epidemiology

Humans

Obsessive-Compulsive Disorder - therapy

Logistic Models

Male

Mood Disorders - epidemiology

Obsessive-Compulsive Disorder - diagnosis

Psychiatric Status Rating Scales

Patient Acceptance of Health Care

Time Factors

Personality Inventory

Age of Onset

Mood Disorders - diagnosis

Sex Factors

Adult

Female

Health Status

Details

Title: Subtitle: Demographic and clinical characteristics associated with treatment status in family members with obsessive-compulsive disorder
Creators: Bernadette Cullen - Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA. bcullen@jhmi.edu
Jack F Samuels
Anthony Pinto
Abby J Fyer
James T McCracken
Scott L Rauch
Dennis L Murphy
Benjamin D Greenberg
James A Knowles
John Piacentini
O Joseph Bienvenu III
Marco A Grados
Mark A Riddle
Steven A Rasmussen
David L Pauls
Virginia L Willour
Yin Y Shugart
Kung-Yee Liang
Rudolf Hoehn-Saric
Gerald Nestadt
Resource Type: Journal article
Publication Details: Depression and anxiety, Vol.25(3), pp.218-224
DOI: 10.1002/da.20293
PMID: 17345603
NLM abbreviation: Depress Anxiety
ISSN: 1091-4269
eISSN: 1520-6394
Publisher: United States
Grant note: RR00052 / NCRR NIH HHS K23-MH64543 / NIMH NIH HHS R01 MH50214 / NIMH NIH HHS
Language: English
Date published: 2008
Academic Unit: Psychiatry; Iowa Neuroscience Institute
Record Identifier: 9984003949602771

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