Journal article
Demographics and Autoantibody Profiles of Pemphigoid Patients with Underlying Neurologic Diseases
Journal of investigative dermatology, Vol.139(9), pp.1860-1866.e1
09/2019
DOI: 10.1016/j.jid.2019.01.034
PMID: 30876802
Abstract
Bullous pemphigoid (BP) is an autoantibody-mediated blistering disease that is often associated with neurologic disease. BP antibodies target two epidermal adhesion molecules, known as BP180 and BP230. Homologues to these proteins are found in the brain, and it is hypothesized that neurologic disease leads to the production of autoantibodies that can cross-react with their cutaneous forms. To better understand the link between BP and neurologic disease, we evaluated primary demographic features (age, sex, race, ethnicity, and elapsed time between onset of skin symptoms and BP diagnosis), severity of BP, and IgG and IgE autoantibody levels in BP control individuals and patients with BP with preceding Parkinson disease, dementia, and stroke. The main findings of this study are that patients with BP with preceding neurologic disease have a shorter elapsed time between onset of skin disease and BP diagnosis and that patients with preceding Parkinson disease or dementia, but not stroke, are significantly older than patients with BP without neurologic disease. However, no significant differences in clinical presentation, BP severity scores, or autoantibody (IgG and IgE) responses were observed among the groups. These findings suggest that, despite the age difference, the clinical phenotype of BP is not affected by preceding neurologic disease.
Details
- Title: Subtitle
- Demographics and Autoantibody Profiles of Pemphigoid Patients with Underlying Neurologic Diseases
- Creators
- Kelly N Messingham - Department of Dermatology, University of Iowa, Iowa City, Iowa, USAAdam D Miller - Department of Dermatology, University of Iowa, Iowa City, Iowa, USANandakumar S Narayanan - Department of Neurology, University of Iowa, Iowa City, Iowa, USASamuel J Connell - Department of Dermatology, University of Iowa, Iowa City, Iowa, USAJanet A Fairley - Department of Dermatology, University of Iowa, Iowa City, Iowa, USA
- Resource Type
- Journal article
- Publication Details
- Journal of investigative dermatology, Vol.139(9), pp.1860-1866.e1
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.jid.2019.01.034
- PMID
- 30876802
- ISSN
- 0022-202X
- eISSN
- 1523-1747
- Grant note
- name: University of Iowa Clinical and Translational Science; DOI: 10.13039/100000002, name: National Institutes of Health, award: U54 TR001356, UL1 TR002537
- Language
- English
- Date published
- 09/2019
- Academic Unit
- Dermatology; Neurology; Iowa Neuroscience Institute
- Record Identifier
- 9984070666202771
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