Demonstration of adenosine receptors on mouse cerebral smooth muscle membranes

D. W BECK; H. V VINTERS; S. A MOORE; M. N HART; F. A HENN; P. A CANCILLA

doi:10.1161/01.STR.15.4.725

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Demonstration of adenosine receptors on mouse cerebral smooth muscle membranes

Journal article

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Peer reviewed

Demonstration of adenosine receptors on mouse cerebral smooth muscle membranes

D. W BECK, H. V VINTERS, S. A MOORE, M. N HART, F. A HENN and P. A CANCILLA

Stroke (1970), Vol.15(4), pp.725-727

1984

DOI: 10.1161/01.STR.15.4.725

PMID: 6087502

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Abstract

Adenosine receptors have been identified on brain cortical membranes and microvascular preparations. However, they have not been demonstrated on specific microvascular elements in isolation. 2-3H-chloroadenosine was used as a ligand to investigate the presence of adenosine receptors on isolated mouse cerebral smooth muscle membranes. The binding studies reveal the presence of a high affinity binding site with a Kd value of 33.3 nM and a maximal binding capacity (Bmax) of 283 fmol/mg protein. These findings demonstrate that there is an adenosine receptor on cerebral smooth muscle membranes.

Fundamental and applied biological sciences. Psychology

Vertebrates: nervous system and sense organs

Biological and medical sciences

Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges

Details

Title: Subtitle: Demonstration of adenosine receptors on mouse cerebral smooth muscle membranes
Creators: D. W BECK - Univ. Iowa City, Iowa hosp. clinics, Iowa City IA 52242, United States
H. V VINTERS - Univ. Iowa City, Iowa hosp. clinics, Iowa City IA 52242, United States
S. A MOORE - Univ. Iowa City, Iowa hosp. clinics, Iowa City IA 52242, United States
M. N HART - Univ. Iowa City, Iowa hosp. clinics, Iowa City IA 52242, United States
F. A HENN - Univ. Iowa City, Iowa hosp. clinics, Iowa City IA 52242, United States
P. A CANCILLA - Univ. Iowa City, Iowa hosp. clinics, Iowa City IA 52242, United States
Resource Type: Journal article
Publication Details: Stroke (1970), Vol.15(4), pp.725-727
Publisher: Lippincott Williams & Wilkins; Hagerstown, MD
DOI: 10.1161/01.STR.15.4.725
PMID: 6087502
ISSN: 0039-2499
eISSN: 1524-4628
Language: English
Date published: 1984
Academic Unit: Pathology
Record Identifier: 9984046816902771

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