Demonstration of motion-compensated volumetric modulated arc radiotherapy on an MR-linac

Pim T.S. Borman; Prescilla Uijtewaal; Jeffrey Snyder; Bryan Allen; Caiden K. Atienza; Peter Woodhead; Daniel E. Hyer; Bas W. Raaymakers; Martin F. Fast

doi:10.1016/j.phro.2025.100729

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Demonstration of motion-compensated volumetric modulated arc radiotherapy on an MR-linac

Journal article

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Demonstration of motion-compensated volumetric modulated arc radiotherapy on an MR-linac

Pim T.S. Borman, Prescilla Uijtewaal, Jeffrey Snyder, Bryan Allen, Caiden K. Atienza, Peter Woodhead, Daniel E. Hyer, Bas W. Raaymakers and Martin F. Fast

Physics and imaging in radiation oncology, Vol.33, 100729

01/2025

DOI: 10.1016/j.phro.2025.100729

PMCID: PMC11880728

PMID: 40046572

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Abstract

Intensity-modulated radiotherapy (IMRT) in combination with magnetic resonance imaging (MRI)-guided gated delivery represents the latest development in the treatment of abdominothoracic tumours on MR-linac. In contrast, volumetric-modulated arc therapy (VMAT) is typically used on conventional linacs due to its superior delivery efficiency and speed. Non-inferior VMAT plans were created in a research treatment planning system for eight lung cancer patients previously treated on an MR-linac. VMAT plans were delivered on a moving dosimeter using respiratory multi-leaf collimator (MLC) tracking. VMAT with MLC tracking achieved an average 2%/2 mm local gamma pass rate of 93% relative to planned dose with a delivery efficiency of 83%.

Lung Cancer

MLC tracking

MR-linac

VMAT

Details

Title: Subtitle: Demonstration of motion-compensated volumetric modulated arc radiotherapy on an MR-linac
Creators: Pim T.S. Borman - University Medical Center Utrecht
Prescilla Uijtewaal - University Medical Center Utrecht
Jeffrey Snyder - Department of Radiation Oncology, Yale New Haven Health, New Haven, CT, USA
Bryan Allen - University of Iowa
Caiden K. Atienza - University of Iowa
Peter Woodhead - University Medical Center Utrecht
Daniel E. Hyer - Department of Radiation Oncology, University of Iowa, Iowa City, IA, USA
Bas W. Raaymakers - University Medical Center Utrecht
Martin F. Fast - University Medical Center Utrecht
Resource Type: Journal article
Publication Details: Physics and imaging in radiation oncology, Vol.33, 100729
DOI: 10.1016/j.phro.2025.100729
PMID: 40046572
PMCID: PMC11880728
NLM abbreviation: Phys Imaging Radiat Oncol
ISSN: 2405-6316
eISSN: 2405-6316
Publisher: Elsevier B.V
Grant note: Elekta ABDutch Research Council (NWO): 20827 IBA Quasar provided the prototype motion platform through ITEA SIGNET: 20052
The authors report research agreements with Elekta AB. UMC Utrecht acknowledges funding by the Dutch Research Council (NWO) through project no. 20827 (ART-PIVOT) . IBA Quasar provided the prototype motion platform through ITEA SIGNET Project Number 20052.
Language: English
Date published: 01/2025
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Radiation Oncology
Record Identifier: 9984790998102771

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