Journal article
Dendritic-cell interactions with HIV: infection and viral dissemination
Nature reviews. Immunology, Vol.6(11), pp.859-868
11/2006
DOI: 10.1038/nri1960
PMCID: PMC1796806
PMID: 17063186
Abstract
Dendritic cells (DCs) are crucial in the generation and regulation of adaptive immunity. Given their pivotal role in marshalling immune responses, HIV has evolved ways to exploit DCs to facilitate viral dissemination and to evade antiviral immunity. Defining the mechanisms that underlie cell–cell transmission of HIV and understanding the role of DCs in this process should help us in the fight against HIV infection. This Review highlights the latest advances in our understanding of the interactions between DCs and HIV, and focuses on the mechanisms of DC-mediated viral dissemination.
Details
- Title: Subtitle
- Dendritic-cell interactions with HIV: infection and viral dissemination
- Creators
- Li Wu - Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, 8701 Watertown Plank Road, BSB 203, Milwaukee, Wisconsin 53226, USAVineet N KewalRamani - HIV Drug Resistance Program, National Cancer Institute, National Institutes of Health, Frederick, Maryland 21702, USA
- Resource Type
- Journal article
- Publication Details
- Nature reviews. Immunology, Vol.6(11), pp.859-868
- DOI
- 10.1038/nri1960
- PMID
- 17063186
- PMCID
- PMC1796806
- NLM abbreviation
- Nat Rev Immunol
- ISSN
- 1474-1733
- eISSN
- 1474-1741
- Language
- English
- Date published
- 11/2006
- Academic Unit
- Microbiology and Immunology
- Record Identifier
- 9984002380502771
Metrics
109 Record Views