Dendritic immune cell densities in the central cornea associated with soft contact lens types and lens care solution types: a pilot study

Christine W Sindt; Trudy K Grout; D Brice Critser; Jami R Kern; David L Meadows

doi:10.2147/OPTH.S28083

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Dendritic immune cell densities in the central cornea associated with soft contact lens types and lens care solution types: a pilot study

Journal article

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Peer reviewed

Dendritic immune cell densities in the central cornea associated with soft contact lens types and lens care solution types: a pilot study

Christine W Sindt, Trudy K Grout, D Brice Critser, Jami R Kern and David L Meadows

Clinical ophthalmology (Auckland, N.Z.), Vol.6(1), pp.511-519

2012

DOI: 10.2147/OPTH.S28083

PMCID: PMC3334229

PMID: 22536045

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Abstract

Background: The purpose of this study was to assess whether differences in central corneal dendritic immune cell densities associated with combinations of soft contact lenses and lens care solutions could be detected by in vivo confocal microscopy. Methods: Participants were adults naïve to contact lens wear (n = 10) or who wore soft contact lenses habitually on a daily-wear schedule (n = 38) or on a study-assigned schedule for 30 days with daily disposable silicone hydrogel lenses (n = 15). Central corneas were scanned using an in vivo confocal microscope. Cell densities were compared among groups by demographic parameters, lens materials, and lens care solutions (polyhexamethylene biguanide [PHMB], polyquaternium-1 and myristamidopropyl dimethylamine [PQ/MAPD], peroxide, or blister pack solution [for daily disposable lenses]). Results: Among lens wearers, no associations were observed between immune cell densities and age, gender, or years of lens-wearing experience. Mean cell density was significantly lower (P < 0.01) in nonwearers (29 ± 23 cells/mm(2), n = 10) than in lens wearers (64 ± 71 cells/mm(2), n = 53). Mean cell density was lower (P = 0.21) with traditional polymer lenses (47 ± 44 cells/mm(2), n = 12) than with silicone hydrogel lenses (69 ± 77 cells/mm(2), n = 41). Lowest to highest mean density of immune cells among lens wearers was as follows: PQ/MAPD solution (49 ± 28 cells/mm(2)), blister pack solution (63 ± 81 cells/mm(2)), PHMB solution (66 ± 44 cells/mm(2)), and peroxide solution (85 ± 112 cells/mm(2)). Conclusion: In this pilot study, in vivo confocal microscopy was useful for detecting an elevated immune response associated with soft contact lenses, and for identifying lens-related and solution-related immune responses that merit further research. Keywords: Clear Care; Langerhans; Opti-Free Replenish; ReNu Multi-Plus; in vivo confocal microscopy.

Clear Care

in vivo confocal microscopy

Langerhans

Opti-Free Replenish

Original Research

ReNu Multi-Plus

Details

Title: Subtitle: Dendritic immune cell densities in the central cornea associated with soft contact lens types and lens care solution types: a pilot study
Creators: Christine W Sindt - University of Iowa Hospitals and Clinics
Trudy K Grout - University of Iowa Hospitals and Clinics
D Brice Critser - University of Iowa Hospitals and Clinics
Jami R Kern - Alcon Research Ltd, Fort Worth, TX, USA
David L Meadows - Alcon Research Ltd, Fort Worth, TX, USA
Resource Type: Journal article
Publication Details: Clinical ophthalmology (Auckland, N.Z.), Vol.6(1), pp.511-519
DOI: 10.2147/OPTH.S28083
PMID: 22536045
PMCID: PMC3334229
NLM abbreviation: Clin Ophthalmol
ISSN: 1177-5467
eISSN: 1177-5483
Publisher: Dove Medical Press
Language: English
Date published: 2012
Academic Unit: The University of Iowa Institute for Vision Research; Ophthalmology and Visual Sciences
Record Identifier: 9984187026602771

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