Journal article
Denosumab Use in Adults With Fibrous Dysplasia: Case Reports and Review of the Literature
Endocrine practice, Vol.28(11), pp.1196-1201
11/2022
DOI: 10.1016/j.eprac.2022.07.012
Abstract
In fibrous dysplasia (FD) of the bone, a gain-of-function mutation in the G-nucleotide binding protein alpha subunit results in constitutively active cyclic adenosine monophosphate. Downstream effects include formation of disorganized cortex and bone marrow fibrosis. Patients with FD experience bone pain and are at risk of fracture. Bisphosphonates are traditionally used to manage pain with mixed results. We sought to report denosumab use in patients with FD at our institution and summarized the existing literature on denosumab use in FD.
We retrospectively identified patients with FD who were treated with denosumab at our institution, describing patient characteristics and outcomes. We reviewed the existing literature on denosumab use in patients with FD.
Patient 1 was diagnosed with FD at the age of 17 years and took bisphosphonates with initial improvement in pain. Pain eventually worsened; therefore, she received 4 doses of denosumab. Patient 2 was diagnosed with FD after a fall and was treated with bisphosphonates, reporting some initial improvement in bone pain. A few years later, the pain recurred, and he received 3 doses of denosumab. Both patients tolerated denosumab well but experienced no improvement in pain. On literature review, although some serious side effects were noted, patients experienced a decline in bone turnover markers, and most reported improvement in bone pain with denosumab.
Denosumab is a promising therapy for managing symptoms of FD. Further studies are needed to determine the optimal dose and duration of treatment. Its long-term effect on FD lesions remains unclear.
Details
- Title: Subtitle
- Denosumab Use in Adults With Fibrous Dysplasia: Case Reports and Review of the Literature
- Creators
- Chermaine Hung - University of IowaAmal Shibli-Rahhal - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Endocrine practice, Vol.28(11), pp.1196-1201
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.eprac.2022.07.012
- ISSN
- 1530-891X
- eISSN
- 1934-2403
- Language
- English
- Date published
- 11/2022
- Academic Unit
- Endocrinology and Metabolism; Medicine Administration; Internal Medicine
- Record Identifier
- 9984359820802771
Metrics
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