Journal article
Dense deposit disease and the factor H H402 allele
Clinical and experimental nephrology, Vol.12(3), pp.228-232
06/2008
DOI: 10.1007/s10157-008-0031-z
PMID: 18224273
Abstract
Herein, we describe the case of an 8-year-old boy who presented with a nephritic nephrotic syndrome. His laboratory investigation was significant for a persistently low serum complement 3 level. A renal biopsy was performed, based on which, he was diagnosed with dense deposit disease/membranoproliferative glomerulonephritis type II (DDD/MPGN II). He was treated with alternate-day oral corticosteroids, angiotensin-converting enzyme (ACE) inhibitors and tacrolimus. Factor H mutational analysis showed the Y402H and I62V allele polymorphisms. The purpose of our report is to discuss the association of the H402 allele variant of factor H with the DDD/MPGN II phenotype and its possible therapeutic implications.
Details
- Title: Subtitle
- Dense deposit disease and the factor H H402 allele
- Creators
- Keith K Lau - Department of Pediatrics, University of California, Davis, 2516 Stockton Blvd., Sacramento, CA 95817, USA. keith.lau@ucdmc.ucdavis.eduRichard J SmithPeter C KolbeckLavjay Butani
- Resource Type
- Journal article
- Publication Details
- Clinical and experimental nephrology, Vol.12(3), pp.228-232
- DOI
- 10.1007/s10157-008-0031-z
- PMID
- 18224273
- NLM abbreviation
- Clin Exp Nephrol
- ISSN
- 1342-1751
- eISSN
- 1437-7799
- Publisher
- Japan
- Language
- English
- Date published
- 06/2008
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Molecular Physiology and Biophysics; Anatomy and Cell Biology; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Otolaryngology; Internal Medicine
- Record Identifier
- 9984006340202771
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