Dental Decay Phenotype in Nonsyndromic Orofacial Clefting

B J Howe; M E Cooper; G L Wehby; J M Resick; N L Nidey; L C Valencia-Ramirez; A M Lopez-Palacio; D Rivera; A R Vieira; S M Weinberg; M L Marazita; L M Moreno Uribe

doi:10.1177/0022034517709961

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Dental Decay Phenotype in Nonsyndromic Orofacial Clefting

Journal article

Open access

Peer reviewed

Dental Decay Phenotype in Nonsyndromic Orofacial Clefting

B J Howe, M E Cooper, G L Wehby, J M Resick, N L Nidey, L C Valencia-Ramirez, A M Lopez-Palacio, D Rivera, A R Vieira, S M Weinberg, …

Journal of dental research, Vol.96(10), pp.1106-1114

09/2017

DOI: 10.1177/0022034517709961

PMCID: PMC5582684

PMID: 28535364

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Abstract

Although children with oral clefts have a higher risk for dental anomalies when compared with the general population, prior studies have shown conflicting results regarding their dental decay risk. Also, few studies have assessed dental decay risk in unaffected relatives of children with clefts. Thus, the question of increased risk of dental decay in individuals with oral clefts or their unaffected relatives is still open for empirical investigation. This study characterizes dental decay in the largest international cohort to date of children with nonsyndromic clefts and their relatives, as compared with controls, and it addresses whether families with oral clefts have a significantly increased risk for dental decay versus the general population. A total of 3,326 subjects were included: 639 case probands, 1,549 unaffected relatives, and 1,138 controls. Decay was identified from in-person dental examinations or intraoral photographs. Case-control differences were tested with regression analysis. No significant differences were shown in percentage decayed and filled teeth and decayed teeth in the primary dentition (dft, dt) and permanent dentition (DFT, DT) in cases versus controls. In the cleft region, no significant differences were seen in primary or permanent decay (dt, DT) when compared with controls. No difference was found with regard to cleft type and percentage dft, dt, DFT, and DT in case probands. Nonsignificant differences were found in unaffected siblings and parents versus controls (primary and permanent dentitions). Collectively, these findings indicate that individuals with nonsyndromic oral clefts and their families do not have a higher dental decay risk as compared with the general population. These results suggest that either genetic or environmental factors underlying a higher susceptibility for dental anomalies do not increase caries risk or that the seemingly higher risk for dental decay associated with increased dental anomalies in case probands may be superseded by possible greater access to dental care.

Phenotype

DMF Index

Disease Susceptibility

Dentition, Permanent

Humans

Risk Factors

Male

Case-Control Studies

Dental Caries - epidemiology

Cleft Palate - complications

Female

Surveys and Questionnaires

Tooth, Deciduous

Cleft Lip - complications

Child

Details

Title: Subtitle: Dental Decay Phenotype in Nonsyndromic Orofacial Clefting
Creators: B J Howe - 2 The Iowa Institute for Oral Health Research, College of Dentistry, University of Iowa, Iowa City, IA, USA
M E Cooper - 3 Center for Craniofacial and Dental Genetics, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, USA
G L Wehby - 4 Department of Health Management and Policy, College of Public Health, University of Iowa, Iowa City, IA, USA
J M Resick - 3 Center for Craniofacial and Dental Genetics, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, USA
N L Nidey - 5 Department of Pediatrics, College of Medicine, University of Iowa, Iowa City, IA, USA
L C Valencia-Ramirez - 6 Fundación Clínica Noel, Medellín, Colombia
A M Lopez-Palacio - 7 Department of Basic Integrated Studies, College of Dentistry, University of Antioquia, Medellin, Colombia
D Rivera - 8 Population Genetics and Mutacarcinogenesis Group, University of Antioquia, Medellin, Colombia
A R Vieira - 9 Department of Oral Biology, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, USA
S M Weinberg - 3 Center for Craniofacial and Dental Genetics, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, USA
M L Marazita - 9 Department of Oral Biology, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, USA
L M Moreno Uribe - 10 Department of Orthodontics, College of Dentistry, University of Iowa, Iowa City, IA, USA
Resource Type: Journal article
Publication Details: Journal of dental research, Vol.96(10), pp.1106-1114
DOI: 10.1177/0022034517709961
PMID: 28535364
PMCID: PMC5582684
NLM abbreviation: J Dent Res
ISSN: 0022-0345
eISSN: 1544-0591
Publisher: United States
Grant note: R37 DE008559 / NIDCR NIH HHS R01 DD000295 / NCBDD CDC HHS R01 DE014667 / NIDCR NIH HHS R01 DE016148 / NIDCR NIH HHS R01 DE008559 / NIDCR NIH HHS
Language: English
Date published: 09/2017
Academic Unit: Preventive and Community Dentistry; Orthodontics; Health Management and Policy; Stead Family Department of Pediatrics; Epidemiology; Economics; Dental Clinic Administration; Addiction Medicine; Craniofacial Anomalies Research Center; Public Policy Center (Archive); Family Dentistry; Dental Research
Record Identifier: 9984025360802771

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