Journal article
Dentin biomodification: strategies, renewable resources and clinical applications
Dental materials, Vol.30(1), pp.62-76
01/2014
DOI: 10.1016/j.dental.2013.10.012
PMCID: PMC3972923
PMID: 24309436
Abstract
The biomodification of dentin is a biomimetic approach, mediated by bioactive agents, to enhance and reinforce the dentin by locally altering the biochemistry and biomechanical properties. This review provides an overview of key dentin matrix components, targeting effects of biomodification strategies, the chemistry of renewable natural sources, and current research on their potential clinical applications.\nThe PubMed database and collected literature were used as a resource for peer-reviewed articles to highlight the topics of dentin hierarchical structure, biomodification agents, and laboratorial investigations of their clinical applications. In addition, new data is presented on laboratorial methods for the standardization of proanthocyanidin-rich preparations as a renewable source of plant-derived biomodification agents.\nBiomodification agents can be categorized as physical methods and chemical agents. Synthetic and naturally occurring chemical strategies present distinctive mechanism of interaction with the tissue. Initially thought to be driven only by inter- or intra-molecular collagen induced non-enzymatic cross-linking, multiple interactions with other dentin components are fundamental for the long-term biomechanics and biostability of the tissue. Oligomeric proanthocyanidins show promising bioactivity, and their chemical complexity requires systematic evaluation of the active compounds to produce a fully standardized intervention material from renewable resource, prior to their detailed clinical evaluation.\nUnderstanding the hierarchical structure of dentin and the targeting effect of the bioactive compounds will establish their use in both dentin-biomaterials interface and caries management.
Details
- Title: Subtitle
- Dentin biomodification: strategies, renewable resources and clinical applications
- Creators
- Ana K Bedran-Russo - Department of Restorative Dentistry, College of Dentistry, University of Illinois at Chicago, Chicago, IL, USAGuido F Pauli - Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, USAShao-Nong Chen - Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, USAJames McAlpine - Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, USACarina S Castellan - Department of Restorative Dentistry, College of Dentistry, University of Illinois at Chicago, Chicago, IL, USARasika S Phansalkar - Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, USAThaiane R Aguiar - Department of Restorative Dentistry, College of Dentistry, University of Illinois at Chicago, Chicago, IL, USACristina M.P Vidal - Department of Restorative Dentistry, College of Dentistry, University of Illinois at Chicago, Chicago, IL, USAJosé G Napotilano - Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, USAJoo-Won Nam - Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, USAAriene A Leme - Department of Restorative Dentistry, College of Dentistry, University of Illinois at Chicago, Chicago, IL, USA
- Resource Type
- Journal article
- Publication Details
- Dental materials, Vol.30(1), pp.62-76
- DOI
- 10.1016/j.dental.2013.10.012
- PMID
- 24309436
- PMCID
- PMC3972923
- NLM abbreviation
- Dent Mater
- ISSN
- 0109-5641
- eISSN
- 1879-0097
- Publisher
- Elsevier Ltd
- Grant note
- name: NIH-NIDCR, award: R01DE021040, DE017740, DE017740-01S4
- Language
- English
- Date published
- 01/2014
- Academic Unit
- Operative Dentistry
- Record Identifier
- 9984065992402771
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