Deoxyglucose Lumped Constant Estimated in a Transplanted Rat Astrocytic Glioma by the Hexose Utilization Index

Alexander M Spence; Michael M Graham; Mark Muzi; Gregory L Abbott; Kenneth A Krohn; Rajesh Kapoor; Steven D Woods

doi:10.1038/jcbfm.1990.34

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Deoxyglucose Lumped Constant Estimated in a Transplanted Rat Astrocytic Glioma by the Hexose Utilization Index

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Deoxyglucose Lumped Constant Estimated in a Transplanted Rat Astrocytic Glioma by the Hexose Utilization Index

Alexander M Spence, Michael M Graham, Mark Muzi, Gregory L Abbott, Kenneth A Krohn, Rajesh Kapoor and Steven D Woods

Journal of cerebral blood flow and metabolism, Vol.10(2), pp.190-198

06/28/2016

DOI: 10.1038/jcbfm.1990.34

PMID: 2303535

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Abstract

The lumped constant (LC) for calculating the regional glucose (glc) metabolic rate by the deoxyglucose (DG) method was estimated in a transplanted rat glioma and normal rat brain. First, the hexose utilization index (HUI) was measured at 1.5, 3.0, and 4.5 min in right hemisphere glioma implants and uninvolved contralateral hemisphere following bolus intravenous injections of [3H]DG and [14C]glucose. At these times, the glioma HUI values were 0.639, 0.732, and 0.712, respectively, and the coordinate left hemisphere values were 0.432, 0.449, and 0.418. Second, the volumes of distribution of DG and glucose were determined to be 0.436 and 0.235 in glioma implants and 0.402 and 0.237 in left hemisphere, respectively. Third, following simultaneous intracarotid injections of [3H]DG and [14C]glucose, the ratio K*1/ K1 was 1.1 in glioma grafts and 1.3 in left hemisphere. With these values for HUI, volume of distribution, and K1 ratio, the LC in this rat glioma was estimated to be 2.1 times higher than the left hemisphere LC ( p < 0.02). These results suggest that measurement of brain tumor CMRglc using a normal brain LC may significantly overestimate the true tumor CMRglc.

Details

Title: Subtitle: Deoxyglucose Lumped Constant Estimated in a Transplanted Rat Astrocytic Glioma by the Hexose Utilization Index
Creators: Alexander M Spence - Division of Neurology and Imaging Research Laboratory, Department of Radiology, University of Washington School of Medicine, Seattle, Washington, U.S.A
Michael M Graham - Division of Neurology and Imaging Research Laboratory, Department of Radiology, University of Washington School of Medicine, Seattle, Washington, U.S.A
Mark Muzi - Division of Neurology and Imaging Research Laboratory, Department of Radiology, University of Washington School of Medicine, Seattle, Washington, U.S.A
Gregory L Abbott - Division of Neurology and Imaging Research Laboratory, Department of Radiology, University of Washington School of Medicine, Seattle, Washington, U.S.A
Kenneth A Krohn - Division of Neurology and Imaging Research Laboratory, Department of Radiology, University of Washington School of Medicine, Seattle, Washington, U.S.A
Rajesh Kapoor - Division of Neurology and Imaging Research Laboratory, Department of Radiology, University of Washington School of Medicine, Seattle, Washington, U.S.A
Steven D Woods - Division of Neurology and Imaging Research Laboratory, Department of Radiology, University of Washington School of Medicine, Seattle, Washington, U.S.A
Resource Type: Journal article
Publication Details: Journal of cerebral blood flow and metabolism, Vol.10(2), pp.190-198
DOI: 10.1038/jcbfm.1990.34
PMID: 2303535
NLM abbreviation: J Cereb Blood Flow Metab
ISSN: 0271-678X
eISSN: 1559-7016
Language: English
Date published: 06/28/2016
Academic Unit: Radiology; Radiation Oncology
Record Identifier: 9984047869202771

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