Journal article
Depressed and anxious mood and T-cell cytokine expressing populations in ovarian cancer patients
Brain, behavior, and immunity, Vol.22(6), pp.890-900
2008
DOI: 10.1016/j.bbi.2007.12.012
PMCID: PMC2605940
PMID: 18276105
Abstract
The adaptive immune response of ovarian cancer patients has been linked to survival, and is known to be impaired in the tumor microenvironment. Little is known about relationships between biobehavioral factors such as depressed mood and anxiety and the adaptive immune response in ovarian cancer. Thirty-seven patients with epithelial ovarian cancer and 14 patients with benign ovarian neoplasms completed psychosocial questionnaires pre-surgery. Lymphocytes from peripheral blood, tumor, and ascites (fluid around the tumor), were obtained on the day of surgery. Expression of the Type-1 cytokine interferon-gamma (IFNγ), and the Type-2 cytokine interleukin-4 (IL-4) by T-helper (CD4
+) and T-cytotoxic (CD8
+) cells was measured under autologous tumor-stimulated, polyclonally-stimulated, or unstimulated conditions. Links with mood were examined. Among cancer patients, marked elevations in unstimulated and tumor-stimulated Type-2 responses were seen, particularly in ascites and tumor-infiltrating lymphocytes (
P values
<
0.01). With polyclonal stimulation, lymphocytes from all compartments expressed elevated Type-1 cytokines (
P values
<
0.014). Depressed and anxious mood were both associated with significantly lower ratios of polyclonally-stimulated CD4
+ cells producing IFNγ (TH
1 cells) vs. IL-4 (TH
2 cells) in all compartments (depressed mood:
P
=
0.012; anxiety:
P
=
0.038) and depressed mood was also related to lower ratios of polyclonally-stimulated CD8
+ cells producing IFNγ (TC
1) vs. IL-4 (TC
2) (
P
=
0.035). Although effects of polyclonal stimulation should be generalized with caution to the
in vivo immune response, findings suggest that depressed and anxious mood are associated with greater impairment of adaptive immunity in peripheral blood and in the tumor microenvironment among ovarian cancer patients.
Details
- Title: Subtitle
- Depressed and anxious mood and T-cell cytokine expressing populations in ovarian cancer patients
- Creators
- Susan K Lutgendorf - Department of Psychology, E11 Seashore Hall, University of Iowa, Iowa City, IA 52242, USADonald M Lamkin - Department of Psychology, E11 Seashore Hall, University of Iowa, Iowa City, IA 52242, USAKoen DeGeest - Department of Obstetrics and Gynecology, E11 Seashore Hall, University of Iowa, Iowa City, IA 52242, USABarrie Anderson - Department of Obstetrics and Gynecology, E11 Seashore Hall, University of Iowa, Iowa City, IA 52242, USAMinh Dao - Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, TX, USAStephanie McGinn - Department of Psychology, E11 Seashore Hall, University of Iowa, Iowa City, IA 52242, USABridget Zimmerman - Department of Biostatistics, University of Iowa, Iowa City, IA, USAHeena Maiseri - Department of Psychology, E11 Seashore Hall, University of Iowa, Iowa City, IA 52242, USAAnil K Sood - Department of Gynecologic Oncology, University of Texas M.D. Anderson Cancer Center, Houston, TX, USADavid M Lubaroff - Department of Urology, E11 Seashore Hall, University of Iowa, Iowa City, IA 52242, USA
- Resource Type
- Journal article
- Publication Details
- Brain, behavior, and immunity, Vol.22(6), pp.890-900
- DOI
- 10.1016/j.bbi.2007.12.012
- PMID
- 18276105
- PMCID
- PMC2605940
- NLM abbreviation
- Brain Behav Immun
- ISSN
- 0889-1591
- eISSN
- 1090-2139
- Publisher
- Elsevier Inc
- Language
- English
- Date published
- 2008
- Academic Unit
- Psychological and Brain Sciences; Iowa Neuroscience Institute; Biostatistics; Obstetrics and Gynecology; Urology
- Record Identifier
- 9983997466802771
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