Depression in elderly persons subject to childhood maltreatment is not modulated by corpus callosum and hippocampal loss

Karen Ritchie; Isabelle Jaussent; Florence Portet; Philippe Courtet; Alain Malafosse; Jerome Maller; Chantal Meslin; Alain Bonafé; Emmanuelle Le Bars; Nicolas Menjot de Champfleur; Sylvaine Artero; Marie-Laure Ancelin

doi:10.1016/j.jad.2012.03.035

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Depression in elderly persons subject to childhood maltreatment is not modulated by corpus callosum and hippocampal loss

Journal article

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Depression in elderly persons subject to childhood maltreatment is not modulated by corpus callosum and hippocampal loss

Karen Ritchie, Isabelle Jaussent, Florence Portet, Philippe Courtet, Alain Malafosse, Jerome Maller, Chantal Meslin, Alain Bonafé, Emmanuelle Le Bars, Nicolas Menjot de Champfleur, …

Journal of affective disorders, Vol.141(2-3), pp.294-9

12/10/2012

DOI: 10.1016/j.jad.2012.03.035

PMID: 22537685

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https://inserm.hal.science/inserm-00704602View

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Abstract

Childhood adversity has been observed to engender structural changes in the hippocampus and corpus callosum associated with increased risk for depression in childhood and early adulthood. This study investigated this association in the elderly. Corpus callosum area and hippocampal volume were measured from structural MRI in 427 community dwelling elderly. Information on childhood adversity was obtained in the course of a clinical examination using a questionnaire covering multiple aspects of abuse. Multivariate analyses found a significant increase in corpus callosum area and hippocampal volume in subjects exposed to mental disorder in parents and poverty, respectively. No association was found with childhood sexual and physical abuse.

Life Sciences

Santé publique et épidémiologie

Details

Title: Subtitle: Depression in elderly persons subject to childhood maltreatment is not modulated by corpus callosum and hippocampal loss
Creators: Karen Ritchie - Université de Montpellier
Isabelle Jaussent - Université de Montpellier
Florence Portet - Université de Montpellier
Philippe Courtet - Université de Montpellier
Alain Malafosse - University of Geneva
Jerome Maller - Monash University
Chantal Meslin - Australian National University
Alain Bonafé - Université de Montpellier
Emmanuelle Le Bars - Université de Montpellier
Nicolas Menjot de Champfleur - Urgence et post-urgence psychiatrique
Sylvaine Artero - Université de Montpellier
Marie-Laure Ancelin - Neuropsychiatrie : Recherche Epidemiologique et Clinique
Resource Type: Journal article
Publication Details: Journal of affective disorders, Vol.141(2-3), pp.294-9
DOI: 10.1016/j.jad.2012.03.035
PMID: 22537685
NLM abbreviation: J Affect Disord
ISSN: 0165-0327
eISSN: 1573-2517
Publisher: Elsevier
Number of pages: -284
Language: English
Date published: 12/10/2012
Academic Unit: Radiology
Record Identifier: 9984848419602771

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