Depression, social support, and beta-adrenergic transcription control in human ovarian cancer

Susan K Lutgendorf; Koen DeGeest; Caroline Y Sung; Jesusa M Arevalo; Frank Penedo; Joseph Lucci; Michael Goodheart; David Lubaroff; Donna M Farley; Anil K Sood; Steve W Cole

doi:10.1016/j.bbi.2008.04.155

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Depression, social support, and beta-adrenergic transcription control in human ovarian cancer

Journal article

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Depression, social support, and beta-adrenergic transcription control in human ovarian cancer

Susan K Lutgendorf, Koen DeGeest, Caroline Y Sung, Jesusa M Arevalo, Frank Penedo, Joseph Lucci, Michael Goodheart, David Lubaroff, Donna M Farley, Anil K Sood, …

Brain Behavior and Immunity, Vol.23(2), pp.176-183

02/2009

DOI: 10.1016/j.bbi.2008.04.155

PMCID: PMC2677379

PMID: 18550328

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Abstract

Motivated by previous indications that beta-adrenergic signaling can regulate tumor cell gene expression in model systems, we sought to determine whether similar dynamics occur in primary human ovarian cancer. DNA microarray analyses of 10 ovarian carcinomas identified 266 human transcripts that were differentially expressed in tumors from patients with elevated biobehavioral risk factors (high depressive symptoms and low social support) relative to grade- and stage-matched tumors from low-risk patients. Promoter-based bioinformatic analyses indicated increased activity of several beta-adrenergically-linked transcription control pathways, including CREB/ATF, NF-κB/Rel, STAT, and Ets family transcription factors. Consistent with increased beta-adrenergic signaling, high biobehavioral risk patients also showed increased intra-tumor concentrations of norepinephrine (but no difference in plasma norepinephrine). These data show that genome-wide transcriptional profiles are significantly altered in tumors from patients with high behavioral risk profiles, and they identify beta-adrenergic signal transduction as a likely mediator of those effects.

Gene Expression

Ovarian Cancer

Beta-adrenergic receptor

Sympathetic nervous system

Transcription factor

Details

Title: Subtitle: Depression, social support, and beta-adrenergic transcription control in human ovarian cancer
Creators: Susan K Lutgendorf - Department of Psychology, University of Iowa, USA
Koen DeGeest - Department of Obstetrics & Gynecology, University of Iowa, USA
Caroline Y Sung - Department of Medicine, Division of Hematology-Oncology, UCLA School of Medicine, and the Norman Cousins Center at UCLA, USA
Jesusa M Arevalo - Department of Medicine, Division of Hematology-Oncology, UCLA School of Medicine, and the Norman Cousins Center at UCLA, USA
Frank Penedo - Department of Psychology, University of Miami, USA
Joseph Lucci - Sylvester Comprehensive Cancer Center, University of Miami, USA
Michael Goodheart - Department of Obstetrics & Gynecology, University of Iowa, USA
David Lubaroff - Department of Obstetrics & Gynecology, University of Iowa, USA
Donna M Farley - Department of Internal Medicine, University of Iowa, USA
Anil K Sood - Department of Gynecologic Oncology, University of Texas M. D. Anderson Cancer Center, USA
Steve W Cole - Department of Medicine, Division of Hematology-Oncology, UCLA School of Medicine, and the Norman Cousins Center at UCLA, USA
Resource Type: Journal article
Publication Details: Brain Behavior and Immunity, Vol.23(2), pp.176-183
DOI: 10.1016/j.bbi.2008.04.155
PMID: 18550328
PMCID: PMC2677379
NLM abbreviation: Brain Behav Immun
ISSN: 0889-1591
eISSN: 1090-2139
Publisher: Elsevier Inc
Language: English
Date published: 02/2009
Academic Unit: Psychological and Brain Sciences; Iowa Neuroscience Institute; Obstetrics and Gynecology; Urology
Record Identifier: 9983930283002771

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