Depressive Symptoms and Longitudinal Changes in Cognition: Women's Health Initiative Study of Cognitive Aging

Joseph S Goveas; Mark A Espeland; Patricia E Hogan; Hilary A Tindle; Regina A Shih; Jane M Kotchen; Jennifer G Robinson; Deborah E Barnes; Susan M Resnick

doi:10.1177/0891988714522697

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Depressive Symptoms and Longitudinal Changes in Cognition: Women's Health Initiative Study of Cognitive Aging

Journal article

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Peer reviewed

Depressive Symptoms and Longitudinal Changes in Cognition: Women's Health Initiative Study of Cognitive Aging

Joseph S Goveas, Mark A Espeland, Patricia E Hogan, Hilary A Tindle, Regina A Shih, Jane M Kotchen, Jennifer G Robinson, Deborah E Barnes and Susan M Resnick

Journal of geriatric psychiatry and neurology, Vol.27(2), pp.94-102

06/2014

DOI: 10.1177/0891988714522697

PMCID: PMC4433445

PMID: 24584465

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Abstract

Elevated depressive symptoms (DS) are associated with incident mild cognitive impairment and probable dementia in postmenopausal women. We examined the association of elevated DS with domain-specific cognitive changes and the moderating role of cardiovascular risk factor severity and cardiovascular disease (CVD). A total of 2221 elderly women who participated in the Women's Health Initiative Study of Cognitive Aging were separated into those with (N = 204) and without (N = 2017) elevated DS. The DS and multidomain cognitive outcomes were measured annually for an average follow-up of 5.04 years. Women with elevated DS showed baseline multidomain cognitive deficits but longitudinal declines in global cognition only. Persistent DS was related to greater global cognition, verbal knowledge and fluency, and memory declines. Significant DS-CVD interactions were observed cross-sectionally (but not longitudinally) for figural memory and fine motor speed. Future studies should investigate the role of nonvascular mechanisms linking DS and cognitive decline.

Severity of Illness Index

Myocardial Infarction - epidemiology

Women's Health

Cross-Sectional Studies

Humans

Risk Factors

Aging - psychology

Dementia - diagnosis

Dementia - epidemiology

Vascular Diseases - epidemiology

Depression - diagnosis

Cognition Disorders - diagnosis

Cognitive Aging - physiology

Cognitive Aging - psychology

Cognitive Dysfunction - epidemiology

Aged, 80 and over

Cardiovascular Diseases - epidemiology

Cognition - physiology

Postmenopause

Female

Aged

Cognitive Dysfunction - diagnosis

Details

Title: Subtitle: Depressive Symptoms and Longitudinal Changes in Cognition: Women's Health Initiative Study of Cognitive Aging
Creators: Joseph S Goveas - Department of Psychiatry and Behavioral Medicine, Medical College of Wisconsin, Milwaukee, WI, USA jgoveas@mcw.edu
Mark A Espeland - Department of Biostatistical Sciences, Wake Forest University Health Sciences, Winston-Salem, NC, USA
Patricia E Hogan - Department of Biostatistical Sciences, Wake Forest University Health Sciences, Winston-Salem, NC, USA
Hilary A Tindle - Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
Regina A Shih - RAND Corporation, Arlington, VA, USA
Jane M Kotchen - Department of Medicine and the Clinical and Translational Science Institute, Medical College of Wisconsin, Milwaukee, WI, USA
Jennifer G Robinson - Department of Epidemiology, University of Iowa, Iowa City, IA, USA
Deborah E Barnes - University of California, San Francisco
Susan M Resnick - Laboratory of Behavioral Neuroscience, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA
Resource Type: Journal article
Publication Details: Journal of geriatric psychiatry and neurology, Vol.27(2), pp.94-102
DOI: 10.1177/0891988714522697
PMID: 24584465
PMCID: PMC4433445
NLM abbreviation: J Geriatr Psychiatry Neurol
ISSN: 0891-9887
eISSN: 1552-5708
Publisher: United States
Grant note: N01WH22110 / WHI NIH HHS UL1 TR000055 / NCATS NIH HHS
Language: English
Date published: 06/2014
Academic Unit: Epidemiology; Internal Medicine
Record Identifier: 9983995166402771

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