Depressive symptoms and cortisol variability prior to surgery for suspected endometrial cancer

Timothy S Sannes; Sally E Jensen; Stacy M Dodd; Shawn M Kneipp; Stephanie Garey Smith; Seema M Patidar; Michael M Marsiske; Susan M Lutgendorf; Linda S Morgan; Deidre B Pereira

doi:10.1016/j.psyneuen.2012.06.001

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Depressive symptoms and cortisol variability prior to surgery for suspected endometrial cancer

Journal article

Open access

Peer reviewed

Depressive symptoms and cortisol variability prior to surgery for suspected endometrial cancer

Timothy S Sannes, Sally E Jensen, Stacy M Dodd, Shawn M Kneipp, Stephanie Garey Smith, Seema M Patidar, Michael M Marsiske, Susan M Lutgendorf, Linda S Morgan and Deidre B Pereira

Psychoneuroendocrinology, Vol.38(2), pp.241-249

02/2013

DOI: 10.1016/j.psyneuen.2012.06.001

PMCID: PMC3473116

PMID: 22762895

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https://www.ncbi.nlm.nih.gov/pmc/articles/3473116View

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Abstract

Endometrial cancer (EC) is the most common type of gynecologic cancer affecting women; however, very little research has examined relationships between psychological factors and hypothalamic–pituitary–adrenal (HPA) axis dysregulation in this population. The current study examined relations between depressive/anxious symptoms and salivary cortisol diurnal rhythm and variability in women undergoing surgery for suspected endometrial cancer. Depressive and anxious symptoms were measured prior to surgery using the Structured Interview Guide for the Hamilton Depression Inventory (SIGH-AD). Saliva was collected four times a day for the 3 days prior to surgery and then assayed by ELISA to obtain cortisol concentrations. Cortisol slopes and intraindividual variability were then calculated across subjects. Relations between depressive/anxious symptoms and cortisol indices were examined using multilevel modeling and linear regression analyses. Participants were 82 women with nonmetastatic endometrial cancer. Anxious symptoms were not associated with either cortisol slope or intraindividual variability, and depressive symptoms were unrelated to cortisol slope. However, after controlling for presence of poorer prognosis cancer subtypes, greater depressive symptoms (excluding symptoms possibly/definitely due to health/treatment factors) in the week preceding surgery were significantly related to greater cortisol intraindividual variability (β=.214; p<.05). These results suggest that depressive symptoms prior to surgery for suspected endometrial cancer are related to greater cortisol intraindividual variability, which is suggestive of more erratic HPA axis arousal. Future research should examine whether mood symptoms may be associated with compromised health outcomes via erratic HPA axis arousal in this population.

Endometrial Cancer

Depression

Cortisol

Anxiety

Intraindividual variability

Details

Title: Subtitle: Depressive symptoms and cortisol variability prior to surgery for suspected endometrial cancer
Creators: Timothy S Sannes - Department of Clinical and Health Psychology, College of Public Health and Health Professions, University of Florida, Gainesville, FL, United States
Sally E Jensen - Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, United States
Stacy M Dodd - Palo Alto VAMC, Palo Alto, CA, United States
Shawn M Kneipp - Health Care Environments Division, School of Nursing, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States
Stephanie Garey Smith - Department of Clinical and Health Psychology, College of Public Health and Health Professions, University of Florida, Gainesville, FL, United States
Seema M Patidar - Department of Clinical and Health Psychology, College of Public Health and Health Professions, University of Florida, Gainesville, FL, United States
Michael M Marsiske - Department of Clinical and Health Psychology, College of Public Health and Health Professions, University of Florida, Gainesville, FL, United States
Susan M Lutgendorf - Department of Psychology, University of Iowa, Iowa City, IA, United States
Linda S Morgan - Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, University of Florida, Gainesville, FL, United States
Deidre B Pereira - Department of Clinical and Health Psychology, College of Public Health and Health Professions, University of Florida, Gainesville, FL, United States
Resource Type: Journal article
Publication Details: Psychoneuroendocrinology, Vol.38(2), pp.241-249
DOI: 10.1016/j.psyneuen.2012.06.001
PMID: 22762895
PMCID: PMC3473116
NLM abbreviation: Psychoneuroendocrinology
ISSN: 0306-4530
eISSN: 1873-3360
Publisher: Elsevier Ltd
Language: English
Date published: 02/2013
Academic Unit: Psychological and Brain Sciences; Iowa Neuroscience Institute; Obstetrics and Gynecology; Urology
Record Identifier: 9984002362302771

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