Journal article
Depressive symptoms, antidepressant use, and future cognitive health in postmenopausal women: the Women's Health Initiative Memory Study
International psychogeriatrics, Vol.24(8), pp.1252-1264
08/2012
DOI: 10.1017/S1041610211002778
PMCID: PMC5800401
PMID: 22301077
Abstract
Background: Antidepressants are commonly prescribed medications in the elderly, but their relationship with incident mild cognitive impairment (MCI) and probable dementia is unknown. Methods: The study cohort included 6,998 cognitively healthy, postmenopausal women, aged 65–79 years, who were enrolled in a hormone therapy clinical trial and had baseline depressive symptoms and antidepressant use history assessments at enrollment, and at least one postbaseline cognitive measurement. Participants were followed annually and the follow-up averaged 7.5 years for MCI and probable dementia outcomes. A central adjudication committee classified the presence of MCI and probable dementia based on extensive neuropsychiatric examination. Results: Three hundred and eighty-three (5%) women were on antidepressants at baseline. Antidepressant use was associated with a 70% increased risk of MCI, after controlling for potential covariates including the degree of depressive symptom severity. Selective serotonin reuptake inhibitors (SSRIs) and tricyclic antidepressants (TCAs) were both associated with MCI (SSRIs: hazard ratios (HR), 1.78 [95% CI, 1.01–3.13]; TCAs: HR, 1.78 [95% CI, 0.99–3.21]). Depressed users (HR, 2.44 [95% CI, 1.24–4.80]), non-depressed users (HR, 1.79 [95% CI, 1.13–2.85]), and depressed non-users (HR, 1.62 [95% CI, 1.13–2.32]) had increased risk of incident MCI. Similarly, all three groups had increased risk of either MCI or dementia, relative to the control cohort. Conclusions: Antidepressant use and different levels of depression severity were associated with subsequent cognitive impairment in a large cohort of postmenopausal women. Future research should examine the role of antidepressants in the depression–dementia relationship and determine if antidepressants can prevent incident MCI and dementia in individuals with late-life depression subtypes with different levels of severity.
Details
- Title: Subtitle
- Depressive symptoms, antidepressant use, and future cognitive health in postmenopausal women: the Women's Health Initiative Memory Study
- Creators
- Joseph S Goveas - 1Department of Psychiatry and Behavioral Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin, USAPatricia E Hogan - 2Department of Biostatistical Sciences, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USAJane M Kotchen - 3Department of Population Health, Medical College of Wisconsin, Milwaukee, Wisconsin, USAJordan W Smoller - 4Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, USANatalie L Denburg - 5Department of Neurology, University of Iowa College of Medicine, Iowa City, Iowa, USAJoAnn E Manson - 6Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USAAruna Tummala - 1Department of Psychiatry and Behavioral Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin, USAW. Jerry Mysiw - 7Department of Physical Medicine and Rehabilitation, Ohio State University Medical Center, Columbus, Ohio, USAJudith K Ockene - 8Division of Preventive and Behavioral Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USANancy F Woods - 9Family and Child Nursing, University of Washington, Seattle, Washington, USAMark A Espeland - 2Department of Biostatistical Sciences, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USASylvia Wassertheil-Smoller - 10Department of Epidemiology and Population Health, Albert Einstein College of Medicine, New York, New York, USA
- Resource Type
- Journal article
- Publication Details
- International psychogeriatrics, Vol.24(8), pp.1252-1264
- Publisher
- Cambridge University Press; Cambridge, UK
- DOI
- 10.1017/S1041610211002778
- PMID
- 22301077
- PMCID
- PMC5800401
- ISSN
- 1041-6102
- eISSN
- 1741-203X
- Number of pages
- 13
- Alternative title
- Antidepressants, depression, and cognitive decline; J. S. Goveas et al.
- Language
- English
- Date published
- 08/2012
- Academic Unit
- Neurology; Psychological and Brain Sciences; Iowa Neuroscience Institute
- Record Identifier
- 9984070509302771
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