Journal article
Depressive symptoms carry an increased risk for suicidal ideation and behavior in bipolar disorder without any additional contribution of mixed symptoms
Journal of affective disorders, Vol.246, pp.775-782
03/01/2019
DOI: 10.1016/j.jad.2018.12.057
PMCID: PMC6914253
PMID: 30623823
Abstract
•Depressive symptoms are a strong and robust predictor of concomitant suicidal ideation and behavior in bipolar disorder.•Mixed depressive and manic symptoms appear to convey no greater risk for suicidal ideation and behavior than that conveyed by the co-occurring depressive symptomatology.•Suicidal ideation and behavior was significantly more frequent in women with manic symptoms than in men with manic symptoms.•Clinicians should pay particular attention to depressive symptoms and syndromes in bipolar disorder for the purpose of suicide risk assessment and management.
Details
- Title: Subtitle
- Depressive symptoms carry an increased risk for suicidal ideation and behavior in bipolar disorder without any additional contribution of mixed symptoms
- Creators
- Jess G Fiedorowicz - Departments of Psychiatry and Internal Medicine, Carver College of Medicine, The University of Iowa, Iowa City, IA, United StatesJane E Persons - Roy J. and Lucille A. Carver College of Medicine, The University of Iowa, Iowa City, IA, United StatesShervin Assari - Department of Psychiatry, University of Michigan, Ann Arbor, MI, United StatesMichael J Ostacher - Bipolar Disorder & Depression Research Program, VA Palo Alto Health System, Palo Alto, CA, United StatesPeter Zandi - Department of Mental Health and Epidemiology, Johns Hopkins Bloomberg School of Public Health, Department of Psychiatry, Johns Hopkins Medicine, Baltimore, MD, United StatesPo W Wang - Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford University, Palo Alto, CA, United StatesMichael E Thase - Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United StatesMark A Frye - Department of Psychiatry & Psychology, Mayo Clinic, Rochester, MN, United StatesWilliam Coryell - Departments of Psychiatry and Internal Medicine, Carver College of Medicine, The University of Iowa, Iowa City, IA, United StatesNational Network of Depression Centers Bipolar Disorders Interest Group
- Resource Type
- Journal article
- Publication Details
- Journal of affective disorders, Vol.246, pp.775-782
- DOI
- 10.1016/j.jad.2018.12.057
- PMID
- 30623823
- PMCID
- PMC6914253
- NLM abbreviation
- J Affect Disord
- ISSN
- 0165-0327
- eISSN
- 1573-2517
- Publisher
- Elsevier B.V
- Grant note
- DOI: 10.13039/100008269, name: Michigan Institute for Clinical Health Research; DOI: 10.13039/100000050, name: National Heart, Lung, and Blood Institute, award: 2P01HL014388; DOI: 10.13039/100006108, name: National Center for Advancing Translational Science, award: U54TR001356, UL1TR002345; DOI: 10.13039/100000025, name: National Institute of Mental Health, award: 1R01MH111578; name: Myriad Genetics, Inc; DOI: 10.13039/100000050, name: National Heart Lung and Blood Institute, award: P01HL014388; name: Institute for Clinical and Translational Science, award: U54TR001356; DOI: 10.13039/100016939, name: Myriad Genetics, Inc.; name: Heinz C. Prechter Bipolar Research Fund; name: Richard Tam Foundation; DOI: 10.13039/100000025, name: National Institute of Mental Health; DOI: 10.13039/100000133, name: Agency for Healthcare Research and Quality; DOI: 10.13039/100006093, name: Patient Centered Outcomes Research Institute; DOI: 10.13039/100009427, name: Acadia; name: Alkermes; name: Assurex; name: Avanir; DOI: 10.13039/100014478, name: Forest Pharmaceuticals; DOI: 10.13039/100004331, name: Johnson & Johnson; name: Otsuka Pharmaceuticals; DOI: 10.13039/100008373, name: Takeda; name: AssureRx; DOI: 10.13039/100007048, name: Mayo Foundation; name: Myriad, National Institute of Alcohol Abuse and Alcoholism; DOI: 10.13039/100000025, name: National Institute of Mental Health; DOI: 10.13039/100004319, name: Pfizer; name: National Network of Depression Centers, award: UL1TR000422; DOI: 10.13039/100008269, name: Michigan Institute for Clinical Health Research
- Language
- English
- Date published
- 03/01/2019
- Academic Unit
- Psychiatry; Epidemiology; Iowa Neuroscience Institute; Internal Medicine
- Record Identifier
- 9984003966302771
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