Journal article
Dermatoglyphic fingerprint heterogeneity among individuals with nonsyndromic cleft lip with or without cleft palate and their unaffected relatives in China and the Philippines
Human biology, Vol.77(2), pp.257-266
04/01/2005
DOI: 10.1353/hub.2005.0042
PMID: 16201141
Abstract
<p>Cleft lip with or without cleft palate (CL/P) is a common birth defect (birth prevalence ranging from 1/500 to 1/2,000) with a complex etiology. Traits potentially related to CL/P, such as dermatoglyphics, may reflect the genetic and epidemiologic heterogeneity observed in CL/P. Such phenotypic heterogeneity in dermatoglyphic patterns may account for some of the variability in previously reported associations of dermatoglyphics and CL/P. To test this hypothesis, we took dermatoglyphic prints from individuals with nonsyndromic CL/P (n = 460) and their unaffected relatives (n = 254) from the Philippines and China. For both samples three raters designated the patterns as arch, ulnar loop, radial loop, whorl, or "other." Chi-square analysis and standard ANOVA were used to investigate heterogeneity between Filipino and Chinese study subjects. The significant associations between particular pattern types and CL/P were not the same in both populations, demonstrating population-specific association of CL/P and dermatoglyphic pattern types. The ANOVA of pattern type included both CL/P cases and their relatives, with affection status, sex, and population group as variables. For each pattern type except arches, population was significant (p < 0.0001); for radial loops, affection status was additionally significant (p < 0.0001). When only CL/P cases were considered, population was again significant for the ulnar loop (p < 0.0001), whorl (p < 0.0001), and "other" (p = 0.0002) patterns. The ANOVAs demonstrate between-population heterogeneity in dermatoglyphic pattern types. These results support our hypothesis that population-specific associations and population heterogeneity in dermatoglyphic patterns exist for CL/P cases and their relatives.</p>
Details
- Title: Subtitle
- Dermatoglyphic fingerprint heterogeneity among individuals with nonsyndromic cleft lip with or without cleft palate and their unaffected relatives in China and the Philippines
- Creators
- N. M. ScottS. M. WeinbergK. NeiswangerC. A. BrandonSandra Daack-Hirsch - University of IowaJeffrey C MurrayYou-e LiuM. L. Marazita
- Resource Type
- Journal article
- Publication Details
- Human biology, Vol.77(2), pp.257-266
- DOI
- 10.1353/hub.2005.0042
- PMID
- 16201141
- NLM abbreviation
- Hum Biol
- ISSN
- 0018-7143
- Copyright
- Copyright © Wayne State University Press, 2005. Posted by permission.
- Language
- English
- Date published
- 04/01/2005
- Academic Unit
- Craniofacial Anomalies Research Center; Nursing; Public Policy Center (Archive)
- Record Identifier
- 9983557357802771
Metrics
404 File views/ downloads
139 Record Views