Journal article
Description of novel class I alleles encountered during routine registry typing in 2007
Tissue antigens, Vol.74(3), pp.238-240
09/01/2009
DOI: 10.1111/j.1399-0039.2009.01296.x
PMID: 19523144
Abstract
Twenty-six novel human leukocyte antigen (HLA) class I alleles are described: 3 HLA-A alleles, 19 HLA-B alleles and 4 HLA-C alleles. Only one of the novel alleles (HLA-B*0753) was found in multiple individuals and likely is not uncommon in the population. Nineteen (similar to 70%) of the 26 novel alleles are single nucleotide substitution variants when compared with their most homologous allele. Four of these single nucleotide variants are silent substitutions, and one creates a null allele. The remaining novel alleles differ from their most similar allele by two to six nucleotide substitutions. Some of the new alleles encode novel codons and unique amino acid changes at polymorphic positions in the HLA-B lows (codons 30, 67 and 72), while HLA-Cw*0347 encodes an amino acid change at a position not previously reported to be polymorphic for this locus.
Details
- Title: Subtitle
- Description of novel class I alleles encountered during routine registry typing in 2007
- Creators
- A. M. Lazaro - Georgetown University Medical CenterY. Xiao - Georgetown University Medical CenterC. Masaberg - Georgetown University Medical CenterL. Nichol - Children's Hospital of PittsburghE. IvaskovaR. Banwart - Iowa City VA Medical CenterE. Field - Iowa City VA Medical CenterJ. Ng - Georgetown University Medical CenterC. K. Hurley - Georgetown University Medical CenterP. E. Posch - Georgetown University Medical Center
- Resource Type
- Journal article
- Publication Details
- Tissue antigens, Vol.74(3), pp.238-240
- Publisher
- Wiley
- DOI
- 10.1111/j.1399-0039.2009.01296.x
- PMID
- 19523144
- ISSN
- 0001-2815
- eISSN
- 1399-0039
- Number of pages
- 3
- Grant note
- C.W. Bill Young Marrow Donor Recruitment and Research Program N00014-07-1-1108 / Office of Naval Research
- Language
- English
- Date published
- 09/01/2009
- Academic Unit
- Immunology; Internal Medicine
- Record Identifier
- 9984359848102771
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