Description of the Age-Related Eye Disease Study 9-step severity scale applied to participants in the Complications of Age-related Macular Degeneration Prevention Trial

Gui-shuang Ying; Maureen G Maguire; Judith Alexander; Revell W Martin; Andrew N Antoszyk; Complications of Age-related Macular Degeneration Prevention Trial Research Group

doi:10.1001/archophthalmol.2009.189

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Description of the Age-Related Eye Disease Study 9-step severity scale applied to participants in the Complications of Age-related Macular Degeneration Prevention Trial

Journal article

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Peer reviewed

Description of the Age-Related Eye Disease Study 9-step severity scale applied to participants in the Complications of Age-related Macular Degeneration Prevention Trial

Gui-shuang Ying, Maureen G Maguire, Judith Alexander, Revell W Martin, Andrew N Antoszyk and Complications of Age-related Macular Degeneration Prevention Trial Research Group

Archives of ophthalmology (1960), Vol.127(9), pp.1147-1151

09/2009

DOI: 10.1001/archophthalmol.2009.189

PMID: 19752423

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Abstract

To describe characteristics of the Age-Related Eye Disease Study (AREDS) 9-step severity scale applied to participants in the Complications of Age-related Macular Degeneration Prevention Trial (CAPT). Eligibility criteria for CAPT required 10 or more large (>or=125 microm) drusen in each eye. Readers graded baseline photographs from all participants and all follow-up photographs from 402 untreated eyes. Drusen and pigment characteristics were used to assign the AREDS scale score. Choroidal neovascularization was identified from fluorescein angiograms. Geographic atrophy involving the macular center was identified from color photographs. Among 1001 untreated eyes, 90% were at steps 5 to 7 at baseline. The 5-year incidence of advanced age-related macular degeneration (AMD) increased with each step from 8% (step 4) to 40% (steps 8 and 9 combined). These rates were similar to those reported in AREDS. Among 261 eyes with all 5 annual photograph gradings available and without progression to advanced AMD, 55% of eyes had scores that indicated improvement at least once. Before progression to advanced AMD, only 32% of 141 eyes either went through step 8 or 9 or had an increase of 2 or more steps from baseline. The AREDS 9-step severity scale was predictive of development of advanced AMD. The AREDS scale has deficiencies as a surrogate outcome for progression to advanced AMD.

Photography

Severity of Illness Index

Macular Degeneration - prevention & control

Choroidal Neovascularization - diagnosis

Follow-Up Studies

Macular Degeneration - classification

Risk Assessment

Humans

Retinal Drusen - classification

Choroidal Neovascularization - prevention & control

Laser Coagulation

Disease Progression

Macular Degeneration - diagnosis

Incidence

Atrophy

Retinal Pigment Epithelium - pathology

Choroidal Neovascularization - classification

Retinal Drusen - diagnosis

Observation

Fluorescein Angiography

Details

Title: Subtitle: Description of the Age-Related Eye Disease Study 9-step severity scale applied to participants in the Complications of Age-related Macular Degeneration Prevention Trial
Creators: Gui-shuang Ying - Scheie EyeInstitute, University ofPennsylvania, Philadelphia, PA 19104-3309, USA. gsying@mail.med.upenn.edu
Maureen G Maguire
Judith Alexander
Revell W Martin
Andrew N Antoszyk
Complications of Age-related Macular Degeneration Prevention Trial Research Group
Contributors: H Culver Boldt (Contributor) - University of Iowa, Ophthalmology and Visual Sciences
Resource Type: Journal article
Publication Details: Archives of ophthalmology (1960), Vol.127(9), pp.1147-1151
DOI: 10.1001/archophthalmol.2009.189
PMID: 19752423
NLM abbreviation: Arch Ophthalmol
ISSN: 0003-9950
eISSN: 1538-3601
Publisher: American Medical Association; United States
Grant note: EY012211 / NEI NIH HHS EY012261 / NEI NIH HHS EY012279 / NEI NIH HHS
Language: English
Date published: 09/2009
Academic Unit: Ophthalmology and Visual Sciences
Record Identifier: 9983980289902771

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