Desensitization at the interface

James R Howe

doi:10.1021/cb6004382

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Journal article

Open access

Peer reviewed

Desensitization at the interface

James R Howe

ACS chemical biology, Vol.1(10), pp.623-626

11/21/2006

DOI: 10.1021/cb6004382

PMID: 17168566

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Abstract

Normal brain function requires the faithful transmission and integration of information on a timescale of milliseconds, and this rapid signaling is mediated by cell membrane receptors that are ligand-gated ion channels. Fast excitatory transmission occurs when synaptically released glutamate opens channels in neighboring neurons, but these channels desensitize rapidly during sustained high-frequency firing. Recent structural data have begun to provide important insights into the molecular mechanisms that underlie channel activation and desensitization.

Cell Membrane - chemistry

Animals

Calcium Channels - metabolism

Models, Chemical

Models, Biological

Humans

Neurons - physiology

Models, Molecular

Receptors, Neurotransmitter - physiology

Brain - physiology

Ion Channel Gating

Synaptic Transmission

Details

Title: Subtitle: Desensitization at the interface
Creators: James R Howe - Department of Pharmacology, Yale University School of Medicine, SHM B-251, 333 Cedar Street, New Haven, Connecticut 06520, USA. james.howe@yale.edu
Resource Type: Journal article
Publication Details: ACS chemical biology, Vol.1(10), pp.623-626
DOI: 10.1021/cb6004382
PMID: 17168566
NLM abbreviation: ACS Chem Biol
ISSN: 1554-8929
eISSN: 1554-8937
Publisher: United States
Language: English
Date published: 11/21/2006
Academic Unit: Surgery
Record Identifier: 9984051592602771

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