Desensitization for the management of clopidogrel hypersensitivity: initial clinical experience

Nicholas E Walker; Mary Beth Fasano; Phillip A Horwitz

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Desensitization for the management of clopidogrel hypersensitivity: initial clinical experience

Journal article

Peer reviewed

Desensitization for the management of clopidogrel hypersensitivity: initial clinical experience

Nicholas E Walker, Mary Beth Fasano and Phillip A Horwitz

The Journal of invasive cardiology, Vol.18(7), pp.341-344

07/2006

PMID: 16816444

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Abstract

Platelet activation and aggregation play an important role in the pathogenesis of arterial thrombosis in coronary, cerebral and peripheral vascular beds. The antiplatelet agent clopidogrel has become a mainstay of treatment for patients with acute coronary syndromes and stroke, and to reduce ischemic complications after percutaneous coronary and peripheral interventions. There are, however, increasing numbers of reports of hypersensitivity reactions to clopidogrel. We present here a protocol for clopidogrel desensitization in isolated cutaneous reactions. Eight patients have completed the protocol successfully. Three subsequently underwent coronary intervention, and all are currently tolerating a daily clopidogrel dose a median of 7.5 months after desensitization. Desensitization may allow for the safe use of clopidogrel in patients with a history of prior cutaneous hypersensitivity reactions.

Drug Hypersensitivity - prevention & control

Exanthema - physiopathology

Ticlopidine - immunology

Ticlopidine - therapeutic use

Humans

Middle Aged

Male

Stroke - drug therapy

Ticlopidine - analogs & derivatives

Dose-Response Relationship, Drug

Time Factors

Exanthema - chemically induced

Ticlopidine - adverse effects

Coronary Disease - drug therapy

Adult

Female

Aged

Platelet Aggregation - drug effects

Platelet Aggregation Inhibitors - therapeutic use

Platelet Aggregation Inhibitors - immunology

Drug Hypersensitivity - physiopathology

Desensitization, Immunologic - methods

Platelet Aggregation Inhibitors - adverse effects

Details

Title: Subtitle: Desensitization for the management of clopidogrel hypersensitivity: initial clinical experience
Creators: Nicholas E Walker - University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA
Mary Beth Fasano
Phillip A Horwitz
Resource Type: Journal article
Publication Details: The Journal of invasive cardiology, Vol.18(7), pp.341-344
PMID: 16816444
ISSN: 1042-3931
eISSN: 1557-2501
Language: English
Date published: 07/2006
Academic Unit: Stead Family Department of Pediatrics; Cardiovascular Medicine; Rheumatology, Allergy, and Immunology; Immunology; Internal Medicine
Record Identifier: 9984093458602771

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