Journal article
Desensitization strategies: is it worth it?
Transplant international, Vol.33(3), pp.251-259
03/01/2020
DOI: 10.1111/tri.13532
PMID: 31553805
Abstract
Preformed donor-specific antibodies (DSAs) limit access to transplantation for thousands of renal transplant patients. While kidney paired donation offers the best strategy for patients with a living donor, for very highly sensitized patients and those without living donors, a strategy of desensitization offers the best hope of transplantation. Removal of DSAs with plasmapheresis, intravenous immunoglobulin and anti-CD20 antibodies can permit successful transplantation. While the clinical outcomes remain inferior to compatible transplant and the costs are significantly greater, when compared with long-term dialysis treatment, these strategies are offer improved survival and are cost-effective given nationally accepted benchmarks.
Details
- Title: Subtitle
- Desensitization strategies: is it worth it?
- Creators
- Sarat Kuppachi - University of IowaDavid A. Axelrod - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Transplant international, Vol.33(3), pp.251-259
- Publisher
- Wiley
- DOI
- 10.1111/tri.13532
- PMID
- 31553805
- ISSN
- 0934-0874
- eISSN
- 1432-2277
- Number of pages
- 9
- Language
- English
- Date published
- 03/01/2020
- Academic Unit
- Stead Family Department of Pediatrics; Surgery; Nephrology; Internal Medicine
- Record Identifier
- 9984322807802771
Metrics
13 Record Views