Journal article
Design and evaluation of a high-flowrate nanoparticle respiratory deposition (NRD) sampler
Journal of aerosol science, Vol.134, pp.72-79
08/2019
DOI: 10.1016/j.jaerosci.2019.04.019
PMCID: PMC10520748
PMID: 37752991
Abstract
A high-flow (10 L/min) nanoparticle respiratory deposition (NRD) sampler was designed and evaluated to achieve reduced limits of quantification (LOQs) for metal nanoparticles. The high-flow NRD consists of an inlet, impactor stage, diffusion stage, and a final filter. An impactor stage with 12 nozzles was designed from theory to achieve a cut-off diameter of 300 nm at 50% particle collection efficiency (d50). Various depths of 37-mm-diameter polyurethane foam cylinders were tested for the diffusion stage to obtain a collection efficiency curve similar to the deposition of nanoparticles in the human respiratory tract, known as the nanoparticulate matter (NPM) criterion. The objective for the final filter was a collection efficiency of near 100% with minimal pressure drop. The collection efficiencies by size and pressure drops were measured for all NRD sampler components. The final design of the impactor stage nozzle achieved a d50 of 305 nm. The collection efficiency for the diffusion stage with a depth of 7 cm when adjusted for presence of the impactor was the closest to the NPM curve with a R2 value of 0.96 and d50 of 43 nm. Chemical analysis of the metal content for foam affirmed that the high-flow NRD sampler required less sampling time to meet metal LOQs than the 2.5 L/min NRD sampler. The final filter with a modified support pad had a collection efficiency near 100%. The overall pressure drop of the sampler of 8.5 kPa (34 in. H2O) could not be handled by commercial personal sampling pumps. Hence the high-flow NRD sampler can be used as an area sampler or without the final filter for collection of nanoparticles.
•A high-flow NRD sampler was designed and tested with a flow rate of 10 L/min.•Collection efficiency of the high-flow NRD sampler mimics the respiratory deposition curve for nanoparticles.•The sampler can be used in low aerosol concentration environments for short (<60 min) durations.
Details
- Title: Subtitle
- Design and evaluation of a high-flowrate nanoparticle respiratory deposition (NRD) sampler
- Creators
- Theresa I Szabo McCollom - Department of Occupational and Environmental Health, The University of Iowa, Iowa City, IA, USALarissa V Stebounova - Department of Occupational and Environmental Health, The University of Iowa, Iowa City, IA, USAJae Hong Park - School of Health Sciences, Purdue University, West Lafayette, IN, USAVicki H Grassian - Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA, USANatalia I Gonzalez-Pech - Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA, USAThomas M Peters - Department of Occupational and Environmental Health, The University of Iowa, Iowa City, IA, USA
- Resource Type
- Journal article
- Publication Details
- Journal of aerosol science, Vol.134, pp.72-79
- DOI
- 10.1016/j.jaerosci.2019.04.019
- PMID
- 37752991
- PMCID
- PMC10520748
- NLM abbreviation
- J Aerosol Sci
- ISSN
- 0021-8502
- eISSN
- 1879-1964
- Publisher
- Elsevier Ltd
- Grant note
- DOI: 10.13039/100000125, name: National Institute for Occupational Safety and Health, award: R01OH010238; DOI: 10.13039/100006803, name: Heartland Center for Occupational Safety and Health, award: T42OH008491
- Language
- English
- Date published
- 08/2019
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Occupational and Environmental Health; Chemistry; Chemical and Biochemical Engineering
- Record Identifier
- 9984214707802771
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