Journal article
Design, combinatorial chemical synthesis and in vitro characterization of novel urea based gelatinase inhibitors
Bioorganic & medicinal chemistry letters, Vol.9(19), pp.2823-2826
1999
DOI: 10.1016/S0960-894X(99)00498-9
PMID: 10522699
Abstract
A novel series of hydroxamate/urea-based inhibitors of gelatinases has been discovered via solid-phase combinatorial chemistry. SAR of P
1′, P
2′, and P
3′ has been exploited and structures different from traditional succinate-based MMP inhibitors have been found.
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Details
- Title: Subtitle
- Design, combinatorial chemical synthesis and in vitro characterization of novel urea based gelatinase inhibitors
- Creators
- Yingsheng Zhang - Pharmaceutical Science Division, School of Pharmacy, University of Wisconsin-Madison, Madison, WI 53706, U.S.ADongmei Li - Department of Biomolecular Chemistry, Medical School, University of Wisconsin-Madison, Madison, WI 53706, U.S.AJon C Houtman - Department of Biomolecular Chemistry, Medical School, University of Wisconsin-Madison, Madison, WI 53706, U.S.ADonald T Witiak - Pharmaceutical Science Division, School of Pharmacy, University of Wisconsin-Madison, Madison, WI 53706, U.S.AJo Seltzer - Division of Dermatology, School of Medicine, Washington University, St. Louis, MO 63110, U.S.APaul J Bertics - Department of Biomolecular Chemistry, Medical School, University of Wisconsin-Madison, Madison, WI 53706, U.S.ACharles T Lauhon - Pharmaceutical Science Division, School of Pharmacy, University of Wisconsin-Madison, Madison, WI 53706, U.S.A
- Resource Type
- Journal article
- Publication Details
- Bioorganic & medicinal chemistry letters, Vol.9(19), pp.2823-2826
- DOI
- 10.1016/S0960-894X(99)00498-9
- PMID
- 10522699
- NLM abbreviation
- Bioorg Med Chem Lett
- ISSN
- 0960-894X
- eISSN
- 1464-3405
- Publisher
- Elsevier Ltd
- Language
- English
- Date published
- 1999
- Academic Unit
- Microbiology and Immunology; Internal Medicine
- Record Identifier
- 9984094658602771
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