Journal article
Design, methods, and conduct of the optic neuritis treatment trial
Controlled clinical trials, Vol.14(2), pp.123-142
04/1993
DOI: 10.1016/0197-2456(93)90015-6
PMID: 8500302
Abstract
The Optic Neuritis Treatment Trial (ONTT) was an investigator-initiated, multi-centered, randomized, controlled clinical trial supported by cooperative agreements and grants. It was designed to evaluate the efficacy and safety of oral prednisone or intravenous methylprednisolone followed by oral prednisone as compared with oral placebo. The primary outcome measures were contrast sensitivity and visual field; secondary measures were visual acuity and color vision. Four hundred fifty-seven patients were followed for a minimum of 6 months and a maximum of 3 years. This article describes the design and the methods used to implement the ONTT.
Details
- Title: Subtitle
- Design, methods, and conduct of the optic neuritis treatment trial
- Creators
- Patricia A Cleary - Biostatistics Center, The George Washington University (P.A.C., D.J.K., J.B.), USARoy W Beck - Biostatistics Center, The George Washington University (P.A.C., D.J.K., J.B.), USAMalcolm M Anderson - Biostatistics Center, The George Washington University (P.A.C., D.J.K., J.B.), USADavid J Kenny - Biostatistics Center, The George Washington University (P.A.C., D.J.K., J.B.), USAJye-yu Backlund - Biostatistics Center, The George Washington University (P.A.C., D.J.K., J.B.), USAOptic Neuritis Study GroupPeter R Gilbert - Biostatistics Center, The George Washington University (P.A.C., D.J.K., J.B.), USA
- Contributors
- Randy H Kardon (Contributor) - University of Iowa, Ophthalmology and Visual Sciences
- Resource Type
- Journal article
- Publication Details
- Controlled clinical trials, Vol.14(2), pp.123-142
- Publisher
- Elsevier Inc
- DOI
- 10.1016/0197-2456(93)90015-6
- PMID
- 8500302
- ISSN
- 0197-2456
- eISSN
- 1879-050X
- Language
- English
- Date published
- 04/1993
- Academic Unit
- Iowa Neuroscience Institute; Ophthalmology and Visual Sciences
- Record Identifier
- 9984070563202771
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