Journal article
Design of the Subpopulations and Intermediate Outcomes in COPD Study (SPIROMICS)
Thorax, Vol.69(5), pp.492-494
05/2014
DOI: 10.1136/thoraxjnl-2013-203897
PMCID: PMC3954445
PMID: 24029743
Abstract
Subpopulations and Intermediate Outcomes in COPD Study (SPIROMICS) is a multicentre observational study of chronic obstructive pulmonary disease (COPD) designed to guide future development of therapies for COPD by providing robust criteria for subclassifying COPD participants into groups most likely to benefit from a given therapy during a clinical trial, and identifying biomarkers/phenotypes that can be used as intermediate outcomes to reliably predict clinical benefit during therapeutic trials. The goal is to enrol 3200 participants in four strata. Participants undergo a baseline visit and three annual follow-up examinations, with quarterly telephone calls. Adjudication of exacerbations and mortality will be undertaken.
Details
- Title: Subtitle
- Design of the Subpopulations and Intermediate Outcomes in COPD Study (SPIROMICS)
- Creators
- David Couper - Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USALisa M LaVange - Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USAMeiLan Han - Division of Pulmonary & Critical Care, University of Michigan, Ann Arbor, Michigan, USAR Graham Barr - Department of Medicine, Columbia University, New York, New York, USAEugene Bleecker - Center for Genomics and Personalized Medicine Research, Wake Forest University, Winston-Salem, New York, USAEric A Hoffman - Department of Radiology, University of Iowa, Iowa City, Iowa, USARichard Kanner - Department of Internal Medicine/Pulmonary and Critical Care Medicine, University of Utah, Salt Lake City, Utah, USAEric Kleerup - Department of Medicine, University of California at Los Angeles, Los Angeles, California, USAFernando J Martinez - Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USAPrescott G Woodruff - Division of Pulmonary, Critical Care, Sleep and Allergy, Department of Medicine, University of California at San Francisco, San Francisco, California, USAStephen Rennard - Division of Pulmonary, Critical Care, Sleep & Allergy, Department of Internal Medicine, University of Nebraska, Omaha, Nebraska, USA
- Resource Type
- Journal article
- Publication Details
- Thorax, Vol.69(5), pp.492-494
- DOI
- 10.1136/thoraxjnl-2013-203897
- PMID
- 24029743
- PMCID
- PMC3954445
- ISSN
- 0040-6376
- eISSN
- 1468-3296
- Language
- English
- Date published
- 05/2014
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Internal Medicine
- Record Identifier
- 9984051976902771
Metrics
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