Design of the Subpopulations and Intermediate Outcome Measures in COPD (SPIROMICS) AIR Study

Alejandro P Comellas; Nadia N Hansel; Laura M Paulin; Amanda J Gassett; Roger D Peng; Neil Alexis; Vincent S Fan; Eugene Bleecker; Russell Bowler; Mark Dransfield; MeiLan K Han; Victor Kim; Jerry A Krishnan; Cheryl Pirozzi; Christopher B Cooper; Fernando Martinez; Prescott G Woodruff; Patrick J Breysse; R Graham Barr; Joel D Kaufman

doi:10.1136/bmjresp-2017-000186

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Design of the Subpopulations and Intermediate Outcome Measures in COPD (SPIROMICS) AIR Study

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Design of the Subpopulations and Intermediate Outcome Measures in COPD (SPIROMICS) AIR Study

Alejandro P Comellas, Nadia N Hansel, Laura M Paulin, Amanda J Gassett, Roger D Peng, Neil Alexis, Vincent S Fan, Eugene Bleecker, Russell Bowler, Mark Dransfield, …

BMJ open respiratory research, Vol.4(1), pp.e000186-e000186

08/2017

DOI: 10.1136/bmjresp-2017-000186

PMCID: PMC5595208

PMID: 28948026

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Abstract

IntroductionPopulation-based epidemiological evidence suggests that exposure to ambient air pollutants increases hospitalisations and mortality from chronic obstructive pulmonary disease (COPD), but less is known about the impact of exposure to air pollutants on patient-reported outcomes, morbidity and progression of COPD.Methods and analysisThe Subpopulations and Intermediate Outcome Measures in COPD (SPIROMICS) Air Pollution Study (SPIROMICS AIR) was initiated in 2013 to investigate the relation between individual-level estimates of short-term and long-term air pollution exposures, day-to-day symptom variability and disease progression in individuals with COPD. SPIROMICS AIR builds on a multicentre study of smokers with COPD, supplementing it with state-of-the-art air pollution exposure assessments of fine particulate matter, oxides of nitrogen, ozone, sulfur dioxide and black carbon. In the parent study, approximately 3000 smokers with and without airflow obstruction are being followed for up to 3 years for the identification of intermediate biomarkers which predict disease progression. Subcohorts undergo daily symptom monitoring using comprehensive daily diaries. The air monitoring and modelling methods employed in SPIROMICS AIR will provide estimates of individual exposure that incorporate residence-specific infiltration characteristics and participant-specific time-activity patterns. The overarching study aim is to understand the health effects of short-term and long-term exposures to air pollution on COPD morbidity, including exacerbation risk, patient-reported outcomes and disease progression.Ethics and disseminationThe institutional review boards of all the participating institutions approved the study protocols. The results of the trial will be presented at national and international meetings and published in peer-reviewed journals.

Details

Title: Subtitle: Design of the Subpopulations and Intermediate Outcome Measures in COPD (SPIROMICS) AIR Study
Creators: Alejandro P Comellas - University of Iowa Carver College of Medicine, Iowa City, Iowa, USA
Nadia N Hansel - Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Laura M Paulin - Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Amanda J Gassett - University of Washington, Seattle, Washington, USA
Roger D Peng - Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA
Neil Alexis - University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA
Vincent S Fan - VA Puget Sound Health Care System, Seattle, Washington, USA
Eugene Bleecker - Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA
Russell Bowler - National Jewish Health, Denver, Colorado, USA
Mark Dransfield - University of Alabama at Birmingham, Birmingham, Alabama, USA
MeiLan K Han - University of Michigan School of Medicine, Ann Arbor, Michigan, USA
Victor Kim - Temple University School of Medicine, Philadelphia, Pennsylvania, USA
Jerry A Krishnan - University of Illinois, Chicago, Illinois, USA
Cheryl Pirozzi - University of Utah Health Sciences Center, Salt Lake City, Utah, USA
Christopher B Cooper - University of California Los Angeles, Los Angeles, California, USA
Fernando Martinez - Weill Medical College, New York City, New York, USA
Prescott G Woodruff - University of California San Francisco School of Medicine, San Francisco, California, USA
Patrick J Breysse - National Center for Environmental Health/Agency for Toxic Substances & Disease Registry, Atlanta, Georgia, USA
R Graham Barr - Columbia University Medicine Center, New York, USA
Joel D Kaufman - University of Washington, Seattle, Washington, USA
Resource Type: Journal article
Publication Details: BMJ open respiratory research, Vol.4(1), pp.e000186-e000186
DOI: 10.1136/bmjresp-2017-000186
PMID: 28948026
PMCID: PMC5595208
NLM abbreviation: BMJ Open Respir Res
ISSN: 2052-4439
eISSN: 2052-4439
Grant note: DOI: 10.13039/100000050, name: National Heart, Lung, and Blood Institute; DOI: 10.13039/100000066, name: National Institute of Environmental Health Sciences
Language: English
Date published: 08/2017
Academic Unit: Pulmonary, Critical Care, and Occupational Medicine; ICTS; Internal Medicine
Record Identifier: 9984094632802771

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