Journal article
Design of the trial of Org 10172 in acute stroke treatment (TOAST)
Controlled clinical trials, Vol.18(4), pp.358-377
1997
DOI: 10.1016/S0197-2456(97)00012-3
PMID: 9257073
Abstract
TOAST is a multicenter, randomized, placebo-controlled clinical trial testing the usefulness of a new antithrombotic drug in improving the outcome of persons with acute ischemic stroke. Until recently, no clinical trial testing a treatment for ischemic stroke had demonstrated efficacy in outcome. Design problems of previously conducted trials with inconclusive results may partly explain their failures. During the design of TOAST, the investigators addressed several issues so the trial could test the treatment accurately. We report the strategies used in designing, implementing, and coordinating the trial.
Details
- Title: Subtitle
- Design of the trial of Org 10172 in acute stroke treatment (TOAST)
- Creators
- Harold P Adams - Division of Cerebrovascular Diseases, Department of Neurology University of Iowa College of Medicine, Iowa City, Iowa USARobert F Woolson - Division of Biostatistics, Department of Preventive Medicine University of Iowa College of Medicine, Iowa City, Iowa USAWilliam R Clarke - Division of Biostatistics, Department of Preventive Medicine University of Iowa College of Medicine, Iowa City, Iowa USAPatricia H Davis - Division of Cerebrovascular Diseases, Department of Neurology University of Iowa College of Medicine, Iowa City, Iowa USABirgitte H Bendixen - Division of Cerebrovascular Diseases, Department of Neurology University of Iowa College of Medicine, Iowa City, Iowa USABetsy B LovePatricia A Wasek - Division of Biostatistics, Department of Preventive Medicine University of Iowa College of Medicine, Iowa City, Iowa USAKarla J Grimsman - Division of Cerebrovascular Diseases, Department of Neurology University of Iowa College of Medicine, Iowa City, Iowa USA
- Resource Type
- Journal article
- Publication Details
- Controlled clinical trials, Vol.18(4), pp.358-377
- Publisher
- Elsevier Inc
- DOI
- 10.1016/S0197-2456(97)00012-3
- PMID
- 9257073
- ISSN
- 0197-2456
- eISSN
- 1879-050X
- Language
- English
- Date published
- 1997
- Academic Unit
- Statistics and Actuarial Science; Neurology; Epidemiology; Iowa Neuroscience Institute; Biostatistics
- Record Identifier
- 9984020743502771
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