Designing Porous Ion Emitters for Thermal Ionization Mass Spectrometry: Evaluating Metal-Organic Frameworks

Kelly McHugh; Dushyant Barpaga; Michael Sinnwell; Steve Shen; Vaithiyalingam Shutthanandan

doi:10.1021/acs.analchem.1c04160

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Designing Porous Ion Emitters for Thermal Ionization Mass Spectrometry: Evaluating Metal-Organic Frameworks

Journal article

Peer reviewed

Designing Porous Ion Emitters for Thermal Ionization Mass Spectrometry: Evaluating Metal-Organic Frameworks

Kelly McHugh, Dushyant Barpaga, Michael Sinnwell, Steve Shen and Vaithiyalingam Shutthanandan

Analytical chemistry (Washington), Vol.94(4), pp.2072-2077

02/01/2022

DOI: 10.1021/acs.analchem.1c04160

PMID: 35044160

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https://www.osti.gov/biblio/1845704View

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Abstract

This work describes the first exploration of metal-organic frameworks (MOFs) as "next-generation" ion emitters for thermal ionization mass spectrometry (TIMS). MOFs were identified as promising candidates for this application given the synthetic control over their desired structural properties. This tunability results in well-ordered, high-surface-area, high-porosity frameworks with targeted sorption affinities. Here, we explored an aluminum-based, bipyridine-containing MOF (MOF-253) with and without incorporating a high work function metal, rhenium (Re). After analysis of an Nd-bearing MOF, we hypothesized that the well-dispersed, sponge-like interconnected network of the degraded structure would enhance Nd ionization more than traditional TIMS loading techniques (i.e., phosphoric acid). Compared to filaments loaded with phosphoric acid that require an additional benzene carburization step, the Nd ionization efficiencies (atoms detected relative to atoms loaded) for heated filaments loaded with MOF-253 were similar (similar to 1%). Electron microscopy after TIMS analysis demonstrated that the MOF was retained on the filament. While these results are preliminary, they demonstrate that MOFs have potential to enhance ionization and exceed the performance of traditional loading techniques by forming nanoporous ion emitters. Thus, further experimentation is likely to exceed this performance through more specific selection of the base MOF structure and modifications to porosity and composition. This work represents a novel application of MOFs and a next step in the pursuit of advanced thermal ionization with potential to expand across the periodic table.

Physical Sciences

Chemistry

Chemistry, Analytical

Science & Technology

Details

Title: Subtitle: Designing Porous Ion Emitters for Thermal Ionization Mass Spectrometry: Evaluating Metal-Organic Frameworks
Creators: Kelly McHugh - Pacific Northwest National Laboratory
Dushyant Barpaga - Pacific Northwest National Laboratory
Michael Sinnwell - University of Iowa
Steve Shen - Pacific Northwest National Laboratory
Vaithiyalingam Shutthanandan - Environmental Molecular Sciences Laboratory
Resource Type: Journal article
Publication Details: Analytical chemistry (Washington), Vol.94(4), pp.2072-2077
DOI: 10.1021/acs.analchem.1c04160
PMID: 35044160
NLM abbreviation: Anal Chem
ISSN: 0003-2700
eISSN: 1520-6882
Publisher: Amer Chemical Soc
Number of pages: 6
Grant note: Laboratory Directed Research and Development Program at Pacific Northwest National Laboratory US DOE Office of Biological and Environmental Research; United States Department of Energy (DOE)
Language: English
Date published: 02/01/2022
Academic Unit: Chemistry
Record Identifier: 9984936616602771

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