Journal article
Desipramine Plasma Levels and Clinical Response: Evidence for a Curvilinear Relationship
Journal of clinical psychopharmacology, Vol.7(3), pp.138-142
06/1987
DOI: 10.1097/00004714-198706000-00003
PMID: 3298326
Abstract
Twenty-six outpatients with major depression completed a 6-week, fixed dose trial of desipramine and provided plasma samples. Recovery after 6 weeks, defined in either of two ways, corresponded to lower desipramine levels, while clinical status at 4 weeks bore no apparent relationship to plasma levels. Upper limits of 140 or 155 ng/ml emerged depending on the outcome measure used. Patients with endogenous depression, those with primary depression, and those with abnormal dexamethasone suppression test results yielded similar therapeutic thresholds, while the sharpest blood level/response relationship emerged in the subgroup with an abnormal escape from dexamethasone.
Details
- Title: Subtitle
- Desipramine Plasma Levels and Clinical Response: Evidence for a Curvilinear Relationship
- Creators
- WILLIAM CORYELLRICK D TURNERARNOLD SHERMAN
- Resource Type
- Journal article
- Publication Details
- Journal of clinical psychopharmacology, Vol.7(3), pp.138-142
- DOI
- 10.1097/00004714-198706000-00003
- PMID
- 3298326
- ISSN
- 0271-0749
- eISSN
- 1533-712X
- Language
- English
- Date published
- 06/1987
- Academic Unit
- Psychiatry
- Record Identifier
- 9984003916002771
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