Journal article
Detection and disaggregation of amyloid fibrils by luminescent amphiphilic platinum(II) complexes
Dalton transactions : an international journal of inorganic chemistry, Vol.53(21), pp.9001-9010
05/07/2024
DOI: 10.1039/d4dt00882k
PMID: 38726661
Appears in UI Libraries Support Open Access
Abstract
Cyclometallated Pt(II) complexes possessing hydrophobic 2-phenylpyridine (ppy) ligands and hydrophilic acetonylacetone (acac) ligands have been investigated for their ability to detect amyloid fibrils
luminescence response. Using hen egg-white lysozyme (HEWL) as a model amyloid protein, Pt(II) complexes featuring benzanilide-substituted ppy ligands and ethylene glycol-functionalized acac ligands demonstrated enhanced luminescence in the presence of HEWL fibrils, whereas Pt(II) complexes lacking complementary hydrophobic/hydrophilic ligand sets displayed little to no emission enhancement. An amphiphilic Pt(II) complex incorporating a bis(ethylene glycol)-derivatized acac ligand was additionally found to trigger restructuring of HEWL fibrils into smaller spherical aggregates. Amphiphilic Pt(II) complexes were generally non-toxic to SH-SY5Y neuroblastoma cells, and several complexes also exhibited enhanced luminescence in the presence of Aβ
fibrils associated with Alzheimer's disease. This study demonstrates that easily prepared and robust (ppy)Pt
(acac) complexes show promising reactivity toward amyloid fibrils and represent attractive molecular scaffolds for design of small-molecule probes targeting amyloid assemblies.
Details
- Title: Subtitle
- Detection and disaggregation of amyloid fibrils by luminescent amphiphilic platinum(II) complexes
- Creators
- Zhuoheng Li - University of IowaAkalanka B Ekanayake - University of IowaAnna E Bartman - University of IowaJonathan A Doorn - University of Iowa, Medicinal and Natural Products ChemistryAlexei V Tivanski - University of Iowa, ChemistryF Christopher Pigge - University of Iowa, Chemistry
- Resource Type
- Journal article
- Publication Details
- Dalton transactions : an international journal of inorganic chemistry, Vol.53(21), pp.9001-9010
- Publisher
- Royal Society of Chemistry
- DOI
- 10.1039/d4dt00882k
- PMID
- 38726661
- eISSN
- 1477-9234
- Language
- English
- Date published
- 05/07/2024
- Academic Unit
- Radiology; Iowa Neuroscience Institute; Pharmaceutical Sciences and Experimental Therapeutics; Chemistry; Medicinal and Natural Products Chemistry
- Record Identifier
- 9984625757002771
Metrics
16 Record Views