Journal article
Detection of K103N in Ugandan women after repeated exposure to single dose nevirapine
AIDS (London), Vol.21(15), pp.2077-2082
2007
DOI: 10.1097/QAD.0b013e3282703847
PMID: 17885298
Abstract
Objectives: Use of single dose nevirapine (SD NVP) for prevention of HIV-1 mother-to-child transmission (pMTCT) is associated with selection of K103N-containing HIV variants. Repeat use of SD NVP for pMTCT may influence emergence and persistence of NVP-resistant variants.
Design: K103N-containing variants were studied in 48 Ugandan women who received SD NVP in the HIVNET 012 trial, and were re-exposed to SD NVP in one (n = 44) or two (n = 4) subsequent pregnancies during a 5-year follow-up study.
Methods: Samples were analyzed using the LigAmp assay (assay cutoff: 0.5% K103N).
Results: Among 44 women who were re-exposed to SD NVP in one subsequent pregnancy, 37.8% had K103N detected within 1 year of SD-NVP re-exposure. Detection of K103N was independently associated with detection of K103N 6-8 weeks after the first SD NVP exposure and with pre-NVP viral load. The portion of women with undetectable K103N by 2 years after SD NVP administration was similar after first versus second use of SD NVP for pMTCT. K103N was undetectable in 93.2% of evaluable women by 3 years of re-exposure. Only two of four women who received SD NVP in two pregnancies during the follow-up study had K103N detected after the last SD NVP exposure.
Conclusions: K103N was detected in some women within 1 year of SD NVP re-exposure, but faded from detection in most women by 3 years after re-exposure. Detection of K103N by 1 year after SD NVP re-exposure was associated with prior selection of K103N-containing variants and with pre-NVP viral load.
Details
- Title: Subtitle
- Detection of K103N in Ugandan women after repeated exposure to single dose nevirapine
- Creators
- Tamara S FLYS - Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United StatesAnthony MWATHA - Statistical Center for HIV/AIDS Research & Prevention, Fred Hutchinson Cancer Res. Ctr, Seattle, Washington, United StatesLaura A GUAY - Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United StatesClemensia NAKABIITO - Department of Paediatrics, Makerere University, Kampala, UgandaDeborah DONNELL - Statistical Center for HIV/AIDS Research & Prevention, Fred Hutchinson Cancer Res. Ctr, Seattle, Washington, United StatesPhilippa MUSOKE - Department of Paediatrics, Makerere University, Kampala, UgandaFrancis MMIRO - Department of Obstetrics and Gynaecology, Makerere University, Kampala, UgandaJ. Brooks JACKSON - Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United StatesSusan H ESHLEMAN - Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States
- Resource Type
- Journal article
- Publication Details
- AIDS (London), Vol.21(15), pp.2077-2082
- Publisher
- Lippincott Williams & Wilkins; Hagerstown, MD
- DOI
- 10.1097/QAD.0b013e3282703847
- PMID
- 17885298
- ISSN
- 0269-9370
- eISSN
- 1473-5571
- Language
- English
- Date published
- 2007
- Academic Unit
- Pathology; VPMA - Administration
- Record Identifier
- 9984047787002771
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