Journal article
Detection of age-dependent changes in healthy adult lungs with diffusion-weighted 3He MRI
Academic radiology, Vol.12(11), pp.1385-1393
11/2005
DOI: 10.1016/j.acra.2005.08.005
PMID: 16253850
Abstract
To investigate changes in lung microstructure in healthy adult subjects with no smoking history using diffusion-weighted 3He MRI.
Diffusion magnetic resonance imaging using hyperpolarized helium 3 (3He) was applied to healthy volunteers to explore the dependence of lung microstructural changes with age, reflected by changes in the apparent diffusion coefficient (ADC) of 3He in lung air spaces. Data from three sites (University of Virginia (UVa), N = 25; University of Wisconsin (UW), N = 8; University of Nottingham (UN), N = 11) were combined in pooled analysis, including a total of N = 44 subjects (age range, 18-69 years; average age, 41.7 +/- 16.7 years).
ADC was found to depend on age at all three sites (UW, R = +0.95, P = .0003; UVa, R = +0.74, P < .0001; UN, R = +0.96, P < .0001). Increases in mean ADCs with age appeared similar across sites (UW, +0.0017 cm2 s(-1) y(-1); UVa, +0.0015 cm2 s(-1) y(-1); pooled, +0.0015 cm2 s(-1) y(-1); P = .71). In a regional analysis performed on UW data, the increase in ADC affected all regions of the lung, but the apical and middle regions showed a greater increase compared with the base of the lung.
Results suggest the observed age dependence of the ADC may be caused by changes in lung microstructure that increase alveolar volume during the aging process.
Details
- Title: Subtitle
- Detection of age-dependent changes in healthy adult lungs with diffusion-weighted 3He MRI
- Creators
- Sean B Fain - University of Wisconsin–MadisonTalissa A Altes - University of VirginiaShilpa R Panth - University of Wisconsin–MadisonMichael D Evans - University of Wisconsin–MadisonBarnaby Waters - University of NottinghamJohn P Mugler IIIFrank R Korosec - University of Wisconsin–MadisonThomas M Grist - University of Wisconsin–MadisonMike SilvermanMichael Salerno - Stanford UniversityJohn Owers-Bradley - University of Nottingham
- Resource Type
- Journal article
- Publication Details
- Academic radiology, Vol.12(11), pp.1385-1393
- DOI
- 10.1016/j.acra.2005.08.005
- PMID
- 16253850
- ISSN
- 1076-6332
- eISSN
- 1878-4046
- Grant note
- Wellcome Trust
- Language
- English
- Date published
- 11/2005
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Electrical and Computer Engineering; Health and Human Physiology
- Record Identifier
- 9984274958002771
Metrics
8 Record Views