Journal article
Detection of pro angiogenic and inflammatory biomarkers in patients with CKD
Scientific reports, Vol.11(1), pp.8786-8786
04/22/2021
DOI: 10.1038/s41598-021-87710-0
PMCID: PMC8062467
PMID: 33888746
Abstract
Cardiovascular disease (CVD) is the most common cause of death in patients with native and post-transplant chronic kidney disease (CKD). To identify new biomarkers of vascular injury and inflammation, we analyzed the proteome of plasma and circulating extracellular vesicles (EVs) in native and post-transplant CKD patients utilizing an aptamer-based assay. Proteins of angiogenesis were significantly higher in native and post-transplant CKD patients versus healthy controls. Ingenuity pathway analysis (IPA) indicated Ephrin receptor signaling, serine biosynthesis, and transforming growth factor-β as the top pathways activated in both CKD groups. Pro-inflammatory proteins were significantly higher only in the EVs of native CKD patients. IPA indicated acute phase response signaling, insulin-like growth factor-1, tumor necrosis factor-α, and interleukin-6 pathway activation. These data indicate that pathways of angiogenesis and inflammation are activated in CKD patients' plasma and EVs, respectively. The pathways common in both native and post-transplant CKD may signal similar mechanisms of CVD.
Details
- Title: Subtitle
- Detection of pro angiogenic and inflammatory biomarkers in patients with CKD
- Creators
- Diana Jalal - Roy J. and Lucille A. Carver College of MedicineBridget Sanford - University of Colorado Anschutz Medical CampusBrandon Renner - University of Colorado Anschutz Medical CampusPatrick Ten Eyck - University of IowaJennifer Laskowski - University of Colorado Anschutz Medical CampusJames Cooper - University of Colorado Anschutz Medical CampusMingyao Sun - University of IowaYousef Zakharia - University of IowaDouglas Spitz - University of IowaAyotunde Dokun - University of IowaMassimo Attanasio - University of IowaKenneth Jones - University of Oklahoma Health Sciences CenterJoshua M Thurman - University of Colorado Anschutz Medical Campus
- Resource Type
- Journal article
- Publication Details
- Scientific reports, Vol.11(1), pp.8786-8786
- DOI
- 10.1038/s41598-021-87710-0
- PMID
- 33888746
- PMCID
- PMC8062467
- NLM abbreviation
- Sci Rep
- ISSN
- 2045-2322
- eISSN
- 2045-2322
- Grant note
- R01 DK125823 / NIDDK NIH HHS R01 DK113586 / NIDDK NIH HHS R01 DK076690 / NIDDK NIH HHS R01 HL134738 / NIH HHS
- Language
- English
- Date published
- 04/22/2021
- Academic Unit
- Molecular Physiology and Biophysics; Hematology, Oncology, and Blood & Marrow Transplantation; Pathology; Biostatistics; Radiation Oncology; Fraternal Order of Eagles Diabetes Research Center; Nephrology; Endocrinology and Metabolism; Internal Medicine
- Record Identifier
- 9984297504202771
Metrics
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