Detection of the Onset of Multiple Sclerosis from SD-OCT Thickness Measurements of the Retinal Nerve Fiber Layer

Johannes Ledolter; Randy Kardon

doi:10.1080/08982112.2012.721042

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Detection of the Onset of Multiple Sclerosis from SD-OCT Thickness Measurements of the Retinal Nerve Fiber Layer

Journal article

Peer reviewed

Detection of the Onset of Multiple Sclerosis from SD-OCT Thickness Measurements of the Retinal Nerve Fiber Layer

Johannes Ledolter and Randy Kardon

Quality Engineering, Vol.25(1), pp.3-10

12/01/2012

DOI: 10.1080/08982112.2012.721042

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Abstract

The cumulative sum (CUSUM) likelihood ratio detector (discussed in Lai [ 1995 ] and Frisen [ 2003 ]) can be used to monitor a process level against linear trend changes. In this article we discuss this detector and its relationship to the standard CUSUM, which guards against step changes in the level; provide software for its implementation; and present a case study that uses this method to detect the onset of multiple sclerosis. The thickness of the retinal nerve fiber layer has been suggested as a diagnostic measure for evaluating the progression of multiple sclerosis. Newly improved optical coherence tomography (OCT) instrumentation using scan averaging and alignment with a reference scan has reduced the short-term measurement variability in the retinal nerve fiber layer thickness to an extent that allows the proposed CUSUM likelihood ratio detector to detect clinically relevant changes over time. We show that this procedure detects such changes quickly and performs better than the traditional CUSUM technique that protects against step changes in the level.

trend changes

CUSUM

cumulative sum likelihood ratio detector

statistical process control

Details

Title: Subtitle: Detection of the Onset of Multiple Sclerosis from SD-OCT Thickness Measurements of the Retinal Nerve Fiber Layer
Creators: Johannes Ledolter - C. Maxwell Stanley Professor of International Operations Management, Department of Management Science/Department of Statistics and Actuarial Science , University of Iowa and Department of Veterans Affairs Medical Center for the Prevention and Treatment of Visual Loss
Randy Kardon - Pomerantz Family Chair in Ophthalmology, Department of Ophthalmology and Visual Sciences , University of Iowa and Department of Veterans Affairs Medical Center for the Prevention and Treatment of Visual Loss
Resource Type: Journal article
Publication Details: Quality Engineering, Vol.25(1), pp.3-10
DOI: 10.1080/08982112.2012.721042
ISSN: 0898-2112
eISSN: 1532-4222
Publisher: Taylor & Francis Group
Language: English
Date published: 12/01/2012
Academic Unit: Statistics and Actuarial Science; Iowa Neuroscience Institute; Business Analytics; Ophthalmology and Visual Sciences
Record Identifier: 9983979916902771

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