Journal article
Detection of trace concentrations of S-nitrosothiols by means of a capacitive sensor
PloS one, Vol.12(10), pp.e0187149-e0187149
2017
DOI: 10.1371/journal.pone.0187149
PMCID: PMC5658150
PMID: 29073241
Abstract
Small molecule S-nitrosothiols are a class of endogenous chemicals in the body, which have been implicated in a variety of biological functions. However, the labile nature of NO and the limits of current detection assays have made studying these molecules difficult. Here we present a method for detecting trace concentrations of S-nitrosothiols in biological fluids. Capacitive sensors when coupled to a semiconducting material represent a method for detecting trace quantities of a chemical in complex solutions. We have taken advantage of the semiconducting and chemical properties of polydopamine to construct a capacitive sensor and associated method of use, which specifically senses S-nitrosothiols in complex biological solutions.
Details
- Title: Subtitle
- Detection of trace concentrations of S-nitrosothiols by means of a capacitive sensor
- Creators
- James M Seckler - Department of Pediatrics, Case Western Reserve University, Cleveland, Ohio, United States of AmericaNikki M Meyer - Department of Pediatrics, Case Western Reserve University, Cleveland, Ohio, United States of AmericaSpencer T Burton - Department of Pediatrics, Case Western Reserve University, Cleveland, Ohio, United States of AmericaJames N Bates - Department of Anesthesia, University of Iowa, Iowa City, Iowa, United States of AmericaBenjamin Gaston - Rainbow Babies and Children's Hospital, Cleveland, Ohio, United States of AmericaStephen J Lewis - Department of Pediatrics, Case Western Reserve University, Cleveland, Ohio, United States of America
- Resource Type
- Journal article
- Publication Details
- PloS one, Vol.12(10), pp.e0187149-e0187149
- DOI
- 10.1371/journal.pone.0187149
- PMID
- 29073241
- PMCID
- PMC5658150
- NLM abbreviation
- PLoS One
- ISSN
- 1932-6203
- eISSN
- 1932-6203
- Publisher
- Public Library of Science; United States
- Grant note
- DOI: 10.13039/100000002, name: National Institutes of Health, award: 1 P01 HL128192; DOI: 10.13039/100000009, name: Foundation for the National Institutes of Health, award: 1P01HL101871; DOI: 10.13039/100000009, name: Foundation for the National Institutes of Health, award: 1T32HL125245
- Language
- English
- Date published
- 2017
- Academic Unit
- Anesthesia
- Record Identifier
- 9984006481702771
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