Detection of two biological markers of intercourse: prostate-specific antigen and Y-chromosomal DNA

Roxanne Jamshidi; Ana Penman-Aguilar; Jeffrey Wiener; Maria F. Gallo; Jonathan M. Zenilman; J.H. Melendez; Margaret Snead; Carolyn M. Black; Denise J. Jamieson; Maurizio Macaluso

doi:10.1016/j.contraception.2013.08.003

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Detection of two biological markers of intercourse: prostate-specific antigen and Y-chromosomal DNA

Journal article

Open access

Peer reviewed

Detection of two biological markers of intercourse: prostate-specific antigen and Y-chromosomal DNA

Roxanne Jamshidi, Ana Penman-Aguilar, Jeffrey Wiener, Maria F. Gallo, Jonathan M. Zenilman, J.H. Melendez, Margaret Snead, Carolyn M. Black, Denise J. Jamieson and Maurizio Macaluso

Contraception (Stoneham), Vol.88(6), pp.749-757

12/01/2013

DOI: 10.1016/j.contraception.2013.08.003

PMCID: PMC5845849

PMID: 24028752

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https://www.ncbi.nlm.nih.gov/pmc/articles/5845849View

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Abstract

Although biological markers of women's exposure to semen from vaginal intercourse have been developed as surrogates for risk of infection or probability of pregnancy, data on their persistence time and clearance are limited. During 2006–2008, 52 couples were enrolled for three 14-day cycles of abstinence from vaginal sex during which women were exposed in the clinic to a specific quantity (10, 100 or 1000 μL) of their partner's semen. Vaginal swabs were collected before and at 1, 6, 12, 24, 48, 72 and 144 h after exposure for testing for prostate-specific antigen (PSA) and Y-chromosome DNA (Yc DNA). Immediately after exposure to 1000 μL of semen, the predicted sensitivity of being PSA positive was 0.96; this decreased to 0.65, 0.44, 0.21 and 0.07 at 6, 12, 24 and 48 h, respectively. Corresponding predicted sensitivity of being Yc DNA positive was 0.72 immediately postexposure; this increased to 0.76 at 1 h postexposure and then decreased to 0.60 (at 6 h), 0.63 (at 12 h), 0.49 (at 24 h), 0.21 (at 48 h), 0.17 (at 72 h) and 0.12 (at 144 h). Overall findings suggest that PSA may be more consistent as a marker of very recent exposure and that Yc DNA is more likely to be detected in the vagina after 12 h postexposure compared to PSA.

Clearance

Prostate-specific antigen

Semen biomarkers

Y-chromosome DNA

Details

Title: Subtitle: Detection of two biological markers of intercourse: prostate-specific antigen and Y-chromosomal DNA
Creators: Roxanne Jamshidi - Johns Hopkins Medicine
Ana Penman-Aguilar - Office of Minority Health and Health Equity
Jeffrey Wiener - Centers for Disease Control and Prevention
Maria F. Gallo - National Center for Chronic Disease Prevention and Health Promotion
Jonathan M. Zenilman - Johns Hopkins University
J.H. Melendez - Johns Hopkins University
Margaret Snead - National Center for Chronic Disease Prevention and Health Promotion
Carolyn M. Black - National Center for Emerging and Zoonotic Infectious Diseases
Denise J. Jamieson - National Center for Chronic Disease Prevention and Health Promotion
Maurizio Macaluso - Cincinnati Children's Hospital Medical Center
Resource Type: Journal article
Publication Details: Contraception (Stoneham), Vol.88(6), pp.749-757
DOI: 10.1016/j.contraception.2013.08.003
PMID: 24028752
PMCID: PMC5845849
NLM abbreviation: Contraception
ISSN: 0010-7824
eISSN: 1879-0518
Publisher: Elsevier Inc
Grant note: name: CDC and the Association of Teachers of Preventive Medicine, award: TS-1327
Language: English
Date published: 12/01/2013
Academic Unit: Obstetrics and Gynecology; VPMA - Administration
Record Identifier: 9984446440902771

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