Journal article
Determinants for Substrate Specificity of Protein Phosphatase 2A
Enzyme research, Vol.2011(1), pp.398751-8
12/01/2011
DOI: 10.4061/2011/398751
PMCID: PMC3132988
PMID: 21755039
Abstract
Protein phosphatase 2A- (PP2A-) catalyzed dephosphorylation of target substrate proteins is widespread and critical for cellular function. PP2A is predominantly found as a heterotrimeric complex of a catalytic subunit (C), a scaffolding subunit (A), and one member of 4 families of regulatory subunits (B). Substrate specificity of the holoenzyme complex is determined by the subcellular locale the complex is confined to, selective incorporation of the B subunit, interactions with endogenous inhibitory proteins, and specific intermolecular interactions between PP2A and target substrates. Here, we discuss recent studies that have advanced our understanding of the molecular determinants for PP2A substrate specificity.
Details
- Title: Subtitle
- Determinants for Substrate Specificity of Protein Phosphatase 2A
- Creators
- Andrew M Slupe - Department of Pharmacology, University of Iowa, 2-432 BSB, Iowa City, IA 52242, USARonald A Merrill - Department of Pharmacology, University of Iowa, 2-432 BSB, Iowa City, IA 52242, USAStefan Strack - Department of Pharmacology, University of Iowa, 2-432 BSB, Iowa City, IA 52242, USA
- Resource Type
- Journal article
- Publication Details
- Enzyme research, Vol.2011(1), pp.398751-8
- Publisher
- SAGE-Hindawi Access to Research
- DOI
- 10.4061/2011/398751
- PMID
- 21755039
- PMCID
- PMC3132988
- ISSN
- 2090-0414
- eISSN
- 2090-0414
- Grant note
- DOI: 10.13039/100000002, name: National Institutes of Health, award: NS43254, T32GM067795
- Language
- English
- Date published
- 12/01/2011
- Academic Unit
- Pathology; Iowa Neuroscience Institute; Neuroscience and Pharmacology
- Record Identifier
- 9984040528602771
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