Journal article
Determinants of generalized fatigue in individuals with symptomatic knee osteoarthritis: The MOST Study
International journal of rheumatic diseases, Vol.23(4), pp.559-568
04/2020
DOI: 10.1111/1756-185X.13797
PMCID: PMC7160026
PMID: 31991526
Abstract
The aim of the study was to identify sociodemographic, disease-related, physical and mental health-related determinants of fatigue at 2-year follow-up in individuals with symptomatic knee osteoarthritis (OA).
A longitudinal analysis of participants with symptomatic knee OA from the Multicenter Osteoarthritis Study (MOST) was conducted to identify predictors of fatigue at 2-year follow-up. Participants self-reported fatigue at baseline for the first time in the MOST cohort and at follow-up using a 0-10 visual analog scale. At baseline, questionnaires on sociodemographics, disease-related symptoms, physical and mental health factors were completed. Data were analyzed using linear regressions with a backwards elimination approach.
Of the 2330 individuals in the MOST cohort at baseline, 576 had symptomatic knee OA and of these, 449 with complete fatigue values at baseline and follow-up were included in this analysis. Minimally important fatigue change (ie, worsening [≥1.13], no change [<0.82 or <1.13] and improvement [≥-0.82]) from baseline to follow-up were unequal within the population (34.5%, 26.9%, 38.5%; χ
[2, N = 449] = 9.32, P = .009). The multiple linear regression showed that baseline fatigue (unstandardized coefficient [Β] = 0.435; 95% confidence interval [CI] 0.348-0.523, P < .001), slow gait speed (Β = -1.124; 95% CI -1.962 to -0.285, P = .009), depressive symptoms (Β = 0.049; 95% CI 0.024-0.075, P < .001) and higher numbers of comorbidities (Β = 0.242; 95% CI 0.045-0.439, P = .016) were significant predictors of greater fatigue at follow-up.
Fatigue is strongly associated with physical- and mental-related health factors. Individualized treatments that include combined psychological and physical function rehabilitation might be modalities for fatigue management.
Details
- Title: Subtitle
- Determinants of generalized fatigue in individuals with symptomatic knee osteoarthritis: The MOST Study
- Creators
- Henrietta O Fawole - Department of Physiotherapy, College of Medical Sciences, University of Benin, Edo State, NigeriaJody L Riskowski - Centre for Living, School of Health and Life Sciences, Glasgow Caledonian University, Glasgow, UKAndrea Dell'Isola - Department of Orthopaedics, Faculty of Medicine, Lund University, Lund, SwedenMartijn P Steultjens - Centre for Living, School of Health and Life Sciences, Glasgow Caledonian University, Glasgow, UKMichael C Nevitt - University of San Francisco, San Francisco, CA, USAJames C Torner - University of Iowa, Iowa City, IA, USACora E Lewis - University of Alabama, Birmingham, AL, USADavid T Felson - Boston University School of Medicine, Boston, MA, USASebastien F M Chastin - Department of Movement and Sports Science, Ghent University, Ghent, Belgium
- Resource Type
- Journal article
- Publication Details
- International journal of rheumatic diseases, Vol.23(4), pp.559-568
- DOI
- 10.1111/1756-185X.13797
- PMID
- 31991526
- PMCID
- PMC7160026
- NLM abbreviation
- Int J Rheum Dis
- ISSN
- 1756-1841
- eISSN
- 1756-185X
- Grant note
- U01 AG018947 / NIA NIH HHS U01 AG018832 / NIA NIH HHS U01AG18947 / National Institutes of Health - National Institutes on Aging REG2016_SHLS3 / Glasgow Caledonian University U01 AG019069 / NIA NIH HHS U01AG18832 / National Institutes of Health - National Institutes on Aging U01AG19069 / National Institutes of Health - National Institutes on Aging U01AG18820 / National Institutes of Health - National Institutes on Aging U01 AG018820 / NIA NIH HHS
- Language
- English
- Date published
- 04/2020
- Academic Unit
- Epidemiology; Surgery; Injury Prevention Research Center; Neurosurgery
- Record Identifier
- 9984214668502771
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