Journal article
Determination of plasma catecholamines and free 3,4-dihydroxyphenylacetic acid in continuously collected human plasma by high performance liquid chromatography with electrochemical detection
Life sciences (1973), Vol.28(5), pp.477-483
02/02/1981
DOI: 10.1016/0024-3205(81)90140-5
PMID: 7207029
Abstract
We have presented a sensitive and relatively simple and inexpensive method for continuous sampling and determination of plasma catecholamines and a major dopamine metabolite, DOPAC. This method provides the basis for determination of the short-term magnitude of catecholamine response as well as the time course of such a response following several physical or psychological interventions. Resting levels of plasma catecholamines--norepinephrine 292 pg/ml, epinephrine 81 pg/ml and dopamine 29 pg/ml--are comparable to those obtained by other methods. Dopamine and free DOPAC were unaffected by physical or psychological interventions while norepinephrine was considerably increased by isometric handgrip, knee bends, and cold pressor and epinephrine increased during knee bends, mental arithmetic, cold pressor, and blood pressure measurement.
Details
- Title: Subtitle
- Determination of plasma catecholamines and free 3,4-dihydroxyphenylacetic acid in continuously collected human plasma by high performance liquid chromatography with electrochemical detection
- Creators
- I N MeffordM M WardL MilesB TaylorM A ChesneyD L KeeganJ D Barchas
- Resource Type
- Journal article
- Publication Details
- Life sciences (1973), Vol.28(5), pp.477-483
- DOI
- 10.1016/0024-3205(81)90140-5
- PMID
- 7207029
- ISSN
- 0024-3205
- eISSN
- 1879-0631
- Language
- English
- Date published
- 02/02/1981
- Academic Unit
- Health Management and Policy
- Record Identifier
- 9984214839702771
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