Journal article
Developing Precision Invasive Neuromodulation for Psychiatry
The journal of neuropsychiatry and clinical neurosciences, Vol.33(3), pp.200-209
05/14/2021
DOI: 10.1176/appi.neuropsych.20100268
PMCID: PMC8576850
PMID: 33985346
Abstract
Psychiatric conditions are common and often disabling. Although great strides have been made in alleviating symptoms with pharmacotherapy and psychotherapeutic approaches, many patients continue to have severe disease burden despite the best therapies available. One of the pervasive challenges to improving treatment is that present diagnostic and therapeutic strategies lag behind our modern conceptualization of the pathophysiology of these disorders. Psychiatric symptoms manifest through activity in specific neural circuits; thus, therapies capable of modulating these circuits are attractive. The investigators reviewed recent advances that facilitate treating medically refractory psychiatric disorders with intracranial neuromodulation in a way that intervenes more directly with the underlying pathophysiology. Specifically, they reviewed the prospects for using intracranial multielectrode arrays to record brain activity with high spatiotemporal resolution and identify circuit-level electrophysiological correlates of symptoms. A causal relationship of circuit electrophysiology to symptoms could then be established by modulating the circuits to disrupt the symptoms. Personalized therapeutic neuromodulation strategies can then proceed in a rational manner with stimulation protocols informed by the underlying circuit-based pathophysiology of the most bothersome symptoms. This strategy would enhance current methods in neurotherapeutics by identifying individualized anatomical targets with symptom-specific precision, circumventing many of the limitations inherent in modern psychiatric nosology and treatment.
Details
- Title: Subtitle
- Developing Precision Invasive Neuromodulation for Psychiatry
- Creators
- Nicholas L Bormann - Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City (Bormann, Trapp); Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, Calif. (Trapp); Department of Neurology, University of Iowa Carver College of Medicine (Narayanan); and Departments of Neurology, Psychiatry, and Pediatrics, University of Iowa Carver College of Medicine (Boes)Nicholas T Trapp - Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City (Bormann, Trapp); Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, Calif. (Trapp); Department of Neurology, University of Iowa Carver College of Medicine (Narayanan); and Departments of Neurology, Psychiatry, and Pediatrics, University of Iowa Carver College of Medicine (Boes)Nandakumar S Narayanan - Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City (Bormann, Trapp); Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, Calif. (Trapp); Department of Neurology, University of Iowa Carver College of Medicine (Narayanan); and Departments of Neurology, Psychiatry, and Pediatrics, University of Iowa Carver College of Medicine (Boes)Aaron D Boes - Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City (Bormann, Trapp); Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, Calif. (Trapp); Department of Neurology, University of Iowa Carver College of Medicine (Narayanan); and Departments of Neurology, Psychiatry, and Pediatrics, University of Iowa Carver College of Medicine (Boes)
- Resource Type
- Journal article
- Publication Details
- The journal of neuropsychiatry and clinical neurosciences, Vol.33(3), pp.200-209
- DOI
- 10.1176/appi.neuropsych.20100268
- PMID
- 33985346
- PMCID
- PMC8576850
- NLM abbreviation
- J Neuropsychiatry Clin Neurosci
- ISSN
- 0895-0172
- eISSN
- 1545-7222
- Language
- English
- Date published
- 05/14/2021
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Neurology; Psychiatry; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Neurology (Pediatrics)
- Record Identifier
- 9984077781402771
Metrics
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