Journal article
Developing and evaluating the construct validity of a dietary pattern predictive of plasma TMAO and choline
Nutrition, metabolism, and cardiovascular diseases, Vol.34(9), pp.2190-2202
05/2024
DOI: 10.1016/j.numecd.2024.05.022
PMID: 39003134
Abstract
The metabolism of choline (highly present in animal products) can produce trimethylamine N-oxide (TMAO), a metabolite with atherosclerotic effects; however, dietary fiber may suppress this metabolic pathway. This study aimed to develop a dietary pattern predictive of plasma TMAO and choline concentrations using reduced rank regression (RRR) and to evaluate its construct validity.
Diet and plasma concentrations of choline (μmol/L) and TMAO (μmol/L) were assessed in 1724 post-menopausal women who participated in an ancillary study within the Women's Health Initiative Observational Study (1993–1998). The TMAO dietary pattern was developed using RRR in half of the sample (Training Sample) and applied to the other half of the sample (Validation Sample) to evaluate its construct validity. Energy-adjusted food groups were the predictor variables and plasma choline and TMAO, the response variables. ANCOVA and linear regression models were used to assess associations between each biomarker and the dietary pattern score. Discretionary fat, potatoes, red meat, and eggs were positively associated with the dietary pattern, while yogurt, fruits, added sugar, and starchy vegetables were inversely associated. Mean TMAO and choline concentrations significantly increased across increasing quartiles of the dietary pattern in the Training and Validation samples. Positive associations between the biomarkers and the TMAO dietary pattern were also observed in linear regression models (Validation Sample: TMAO, adjusted beta-coefficient = 0.03650 (p-value = 0.0088); Choline, adjusted beta-coefficient = 0.01083 (p-value = 0.0224).
We established the TMAO dietary pattern, a dietary pattern reflecting the potential of the diet to contribute to plasma concentrations of TMAO and choline.
•A diet pattern was created in post-menopausal women to predict plasma biomarkers.•The biomarkers used for development were trimethylamine N-oxide and choline.•The diet pattern consists of high intake of fat, red meat, and eggs.•The diet pattern consists of low intake of yogurt, fruit, and starchy vegetables.•The construct validity of this proposed atherogenic diet pattern was demonstrated.
Details
- Title: Subtitle
- Developing and evaluating the construct validity of a dietary pattern predictive of plasma TMAO and choline
- Creators
- Kaelyn F. Burns - University at Buffalo, State University of New YorkMichael J. LaMonte - University at Buffalo, State University of New YorkRachael Hageman Blair - University at Buffalo, State University of New YorkFred K. Tabung - The Ohio State UniversityKathryn M. Rexrode - Brigham and Women's HospitalLinda G. Snetselaar - University of IowaAmy E. Millen - University at Buffalo, State University of New York
- Resource Type
- Journal article
- Publication Details
- Nutrition, metabolism, and cardiovascular diseases, Vol.34(9), pp.2190-2202
- DOI
- 10.1016/j.numecd.2024.05.022
- PMID
- 39003134
- NLM abbreviation
- Nutr Metab Cardiovasc Dis
- ISSN
- 0939-4753
- eISSN
- 1590-3729
- Publisher
- Elsevier B.V
- Grant note
- National Heart, Lung, and Blood Institute, National Institutes of Health, U.S. Department of Health and Human Services: 75N92021D00001, 75N92021D000 02, 75N92021D000 03, 75N92021D00004, 75N92021D000 05 National Institute of Health: R01 CA120523, N01 WH22110 Kirschstein National Research Service Award from the National Heart, Lung, and Blood Institute (National Institutes of Health, Bethesda, MD): 1F31HL168805
The WHI program is funded by the National Heart, Lung, and Blood Institute, National Institutes of Health, U.S. Department of Health and Human Services through 75N92021D00001, 75N92021D000 02, 75N92021D000 03, 75N92021D00004, 75N92021D000 05. This work was supported by the National Institute of Health R01 CA120523 and N01 WH22110. Kaelyn Burns is supported by a Kirschstein National Research Service Award from the National Heart, Lung, and Blood Institute (National Institutes of Health, Bethesda, MD) [1F31HL168805] . The supporting source had no involvement in the research or restrictions regarding publication.
- Language
- English
- Electronic publication date
- 05/2024
- Academic Unit
- Epidemiology; Fraternal Order of Eagles Diabetes Research Center; Internal Medicine
- Record Identifier
- 9984647960202771
Metrics
11 Record Views