Journal article
Development and Characterization of a Novel Composite Hydrogel Biomaterial for Improved Mucoperiosteal Wound Repair
Journal of biomedical materials research. Part B, Applied biomaterials, Vol.112(9), e35476
09/2024
DOI: 10.1002/jbm.b.35476
PMCID: PMC11407746
PMID: 39223753
Appears in UI Libraries Support Open Access
Abstract
ABSTRACT Mucoperiosteal wound healing, as it occurs after pediatric cleft palate surgery, can be challenging due to the limitations of current treatments such as tissue flaps secured with sutures and fibrin glue. In this study, we characterized the in vitro performance of a novel composite hydrogel biomaterial designed to be employed as an in situ wound filler and enhance mucoperiosteal wound healing. We evaluated a range of photopolymerizable formulations containing methacrylated gelatin (GelMA), glycol chitosan, and bioglass microparticles. Our aim was to identify one or more formulations with an appropriate balance of properties against a set of functional requirements that we established for this application. To test the formulations against these criteria, we measured photopolymerization kinetics, mechanical properties, degradation rate, in vitro biocompatibility, and ex vivo tissue adhesion. All formulations polymerized in less than 90 s using violet light. In addition, we found that GelMA‐based hydrogels were more adhesive to mucoperiosteal tissue than clinical standard fibrin glue. Inclusion of small amounts of bioglass in the formulation increased mechanical compatibility with mucoperiosteal tissue, enhanced cytoconductivity, and promoted cell proliferation. Taken together, our results support the suitability of these photopolymerized composite hydrogels as in situ mucoperiosteal wound fillers. Overall, this study lays the groundwork for investigating the in vivo, pre‐clinical effectiveness of these composite hydrogels in improving mucoperiosteal wound healing outcomes.
Details
- Title: Subtitle
- Development and Characterization of a Novel Composite Hydrogel Biomaterial for Improved Mucoperiosteal Wound Repair
- Creators
- Q. Wang - University of IowaM. Dunnwald - University of Iowa, Anatomy and Cell BiologyD. S. F. Kacmarynski - University of Iowa, OtolaryngologyK. S. Worthington - Roy J. Carver Department of Biomedical Engineering, College of Engineering The University of Iowa Iowa City IA USA
- Resource Type
- Journal article
- Publication Details
- Journal of biomedical materials research. Part B, Applied biomaterials, Vol.112(9), e35476
- DOI
- 10.1002/jbm.b.35476
- PMID
- 39223753
- PMCID
- PMC11407746
- NLM abbreviation
- J Biomed Mater Res B Appl Biomater
- ISSN
- 1552-4973
- eISSN
- 1552-4981
- Publisher
- Wiley; HOBOKEN
- Grant note
- National Institutes of Health: T32 GM007337, T32 HL144461, R01 AR067739
This work was funded by the Lee K. Plaehn Speech Research Fund, University of Iowa Center for Advancement, the National Institutes of Health (T32 GM007337, Q.W.; T32 HL144461, Q.W.; R01 AR067739, M.D.), and the Roy J. Carver Charitable Trust (Department of Biomedical Engineering Carver Graduate Fellowship, Q.W.).
- Language
- English
- Date published
- 09/2024
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Anatomy and Cell Biology; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Craniofacial Anomalies Research Center; Chemical and Biochemical Engineering; Otolaryngology
- Record Identifier
- 9984701560002771
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