Development and Evolution of Inner Ear Sensory Epithelia and Their Innervation

B Fritzsch; K. W Beisel; K Jones; I Fariñas; A Maklad; J Lee; L. F Reichardt

doi:10.1002/neu.10098

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Development and Evolution of Inner Ear Sensory Epithelia and Their Innervation

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Development and Evolution of Inner Ear Sensory Epithelia and Their Innervation

B Fritzsch, K. W Beisel, K Jones, I Fariñas, A Maklad, J Lee and L. F Reichardt

Journal of neurobiology, Vol.53(2), pp.143-156

11/05/2002

DOI: 10.1002/neu.10098

PMCID: PMC4943216

PMID: 12382272

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Abstract

The development and evolution of the inner ear sensory patches and their innervation is reviewed. Recent molecular developmental data suggest that development of these sensory patches is a developmental recapitulation of the evolutionary history. These data suggest that the ear generates multiple, functionally diverse sensory epithelia by dividing a single sensory primordium. Those epithelia will establish distinct identities through the overlapping expression of genes of which only a few are currently known. One of these distinctions is the unique pattern of hair cell polarity. A hypothesis is presented on how the hair cell polarity may relate to the progressive segregation of the six sensory epithelia. Besides being markers for sensory epithelia development, neurotrophins are also expressed in delaminating cells that migrate toward the developing vestibular and cochlear ganglia. These delaminating cells originate from multiple sites at or near the developing sensory epithelia and some also express neuronal markers such as\nNeuroD\n. The differential origin of precursors raises the possibility that some sensory neurons acquire positional information before they delaminate the ear. Such an identity of these delaminating sensory neurons may be used both to navigate their dendrites to the area they delaminated from, as well as to help them navigate to their central target. The navigational properties of sensory neurons as well as the acquisition of discrete sensory patch phenotypes implies a much more sophisticated subdivision of the developing otocyst than the few available gene expression studies suggest.

ear development

ear sensory neurons

sensory neuron migration

sensory neuron projection

Details

Title: Subtitle: Development and Evolution of Inner Ear Sensory Epithelia and Their Innervation
Creators: B Fritzsch - Department of Biomedical Sciences, Creighton University, Omaha, Nebraska 68178
K. W Beisel - Department of Genetics, Boystown National Research Hospital, Omaha, Nebraska 8131
K Jones - Department of Biology, University of Boulder, Boulder, Colorado 80309
I Fariñas - Biologia Celular, Universidad de Valencia, Burjassot, 46100, Spain
A Maklad - Department of Biomedical Sciences, Creighton University, Omaha, Nebraska 68178
J Lee - Department of Biology, University of Boulder, Boulder, Colorado 80309
L. F Reichardt - University of California, San Francisco, California 94143
Resource Type: Journal article
Publication Details: Journal of neurobiology, Vol.53(2), pp.143-156
DOI: 10.1002/neu.10098
PMID: 12382272
PMCID: PMC4943216
NLM abbreviation: J Neurobiol
ISSN: 0022-3034
eISSN: 1097-4695
Publisher: Wiley
Grant note: DOI: 10.13039/100000055, name: NIDCD, award: 2P01 DC00215, R01 DC04279
Language: English
Date published: 11/05/2002
Academic Unit: Iowa Neuroscience Institute; Biology; Craniofacial Anomalies Research Center; Obstetrics and Gynecology
Record Identifier: 9984070140102771

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