Development of Alcohol Use Disorder as a Function of Age, Severity, and Comorbidity with Externalizing and Internalizing Disorders in a Young Adult Cohort

John I Nurnberger Jr; Ziyi Yang; Yong Zang; Laura Acion; Laura Bierut; Kathleen Bucholz; Grace Chan; Danielle M Dick; Howard J Edenberg; John Kramer; Samuel Kuperman; John P Rice; Marc Schuckit

doi:10.20900/jpbs.20190016

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Development of Alcohol Use Disorder as a Function of Age, Severity, and Comorbidity with Externalizing and Internalizing Disorders in a Young Adult Cohort

Journal article

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Development of Alcohol Use Disorder as a Function of Age, Severity, and Comorbidity with Externalizing and Internalizing Disorders in a Young Adult Cohort

John I Nurnberger Jr, Ziyi Yang, Yong Zang, Laura Acion, Laura Bierut, Kathleen Bucholz, Grace Chan, Danielle M Dick, Howard J Edenberg, John Kramer, …

Journal of psychiatry and brain science, Vol.4, e190016

2019

DOI: 10.20900/jpbs.20190016

PMCID: PMC6919651

PMID: 31853508

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Abstract

As part of the ongoing Collaborative Study of the Genetics of Alcoholism, we performed a longitudinal study of a high risk cohort of adolescents/young adults from families with a proband with an alcohol use disorder, along with a comparison group of age-matched controls. The intent was to compare the development of alcohol problems in subjects at risk with and without comorbid externalizing and internalizing psychiatric disorders. Subjects ( = 3286) were assessed with a structured psychiatric interview at 2 year intervals over 10 years (2004-2017). The age range at baseline was 12-21. Subjects with externalizing disorders (with or without accompanying internalizing disorders) were at increased risk for the onset of an alcohol use disorder during the observation period. Subjects with internalizing disorders were at greater risk than those without comorbid disorders for onset of a moderate or severe alcohol use disorder. The statistical effect of comorbid disorders was greater in subjects with more severe alcohol use disorders. The developmental trajectory of drinking milestones and alcohol use disorders was also accelerated in those with more severe disorders. These results may be useful for counseling of subjects at risk who present for clinical care, especially those subjects manifesting externalizing and internalizing disorders in the context of a positive family history of an alcohol use disorder. We confirm and extend findings that drinking problems in subjects at greatest risk will begin in early adolescence.

high risk studies

internalizing disorders

alcohol use disorders

externalizing disorders

family studies

Details

Title: Subtitle: Development of Alcohol Use Disorder as a Function of Age, Severity, and Comorbidity with Externalizing and Internalizing Disorders in a Young Adult Cohort
Creators: John I Nurnberger Jr - Departments of Psychiatry and Medical and Molecular Genetics and Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Ziyi Yang - Department of Biostatistics, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Yong Zang - Department of Biostatistics, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Laura Acion - University of Iowa, Psychiatry
Laura Bierut - Department of Psychiatry, Washington University in St. Louis School of Medicine, St. Louis, MO 63110, USA
Kathleen Bucholz - Department of Psychiatry, Washington University in St. Louis School of Medicine, St. Louis, MO 63110, USA
Grace Chan - University of Iowa, Psychiatry
Danielle M Dick - Department of Psychology, Virginia Commonwealth University, Richmond, VA 23284, USA
Howard J Edenberg - Departments of Biochemistry and Molecular Biology and Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA
John Kramer - University of Iowa, Psychiatry
Samuel Kuperman - University of Iowa, Psychiatry
John P Rice - Department of Psychiatry, Washington University in St. Louis School of Medicine, St. Louis, MO 63110, USA
Marc Schuckit - Department of Psychiatry, University of California San Diego School of Medicine, La Jolla, CA 92093, USA
Resource Type: Journal article
Publication Details: Journal of psychiatry and brain science, Vol.4, e190016
DOI: 10.20900/jpbs.20190016
PMID: 31853508
PMCID: PMC6919651
NLM abbreviation: J Psychiatr Brain Sci
ISSN: 2398-385X
eISSN: 2398-385X
Grant note: U10 AA008401 / NIAAA NIH HHS
Language: English
Date published: 2019
Academic Unit: Psychiatry; Stead Family Department of Pediatrics
Record Identifier: 9984130701302771

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