Journal article
Development of Blood Coagulation—A Fetal Lamb Model
Pediatric research, Vol.15(7), pp.1045-1050
07/1981
DOI: 10.1203/00006450-198107000-00014
PMID: 7254950
Abstract
To study the normal development of blood coagulation factor activities in a growing fetus while avoiding the effects of labor and delivery, a chronic fetal lamb model was developed in which serial blood samples from 10 fetuses were studied during the third trimester of pregnancy and 24 hr after birth. Under operating room conditions with sterile technique, a polyethylene catheter to which heparin had been bound to both internal and external surfaces was inserted into the femoral artery of the fetus. The catheter was brought out through a skin pouch to the side of the ewe and enclosed in a zip lock bag. Blood samples were withdrawn from the catheter three times each week for measurement of coagulation factor activities. Levels of coagulation factor activities at birth in noncatheterized animals were not different from those found in catheterized animals except for factor IX activity which was 12% higher in the catheterized animals (0.02 less than P less than 0.05). The patterns of development for each of the coagulation factors were similar in all 10 animals studied. Fibrinogen, prothrombin, and factor VII show a decrease in activity early in the last trimester of pregnancy. Both factors VIII and IX show a significant increase in activity (23% factor VIII and 12% factor IX) associated with the process of delivery. The levels of coagulation factor activities at birth in the lamb relative to adult sheep normals are similar to those found in humans with the exception of factor XIII. Factor XIII is at normal levels in the newborn lamb and is reported to be at levels approximately 50% of the adult level in human infants
Details
- Title: Subtitle
- Development of Blood Coagulation—A Fetal Lamb Model
- Creators
- C Thomas Kisker - University of IowaJean E Robillard - University of IowaWilliam R Clarke - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Pediatric research, Vol.15(7), pp.1045-1050
- DOI
- 10.1203/00006450-198107000-00014
- PMID
- 7254950
- ISSN
- 0031-3998
- eISSN
- 1530-0447
- Number of pages
- 6
- Language
- English
- Date published
- 07/1981
- Academic Unit
- Molecular Physiology and Biophysics; Nephrology, Dialysis and Transplantation; Stead Family Department of Pediatrics; Medicine Administration
- Record Identifier
- 9984773402202771
Metrics
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