Journal article
Development of Potential Small Molecule Therapeutics for Treatment of Ebola Virus Disease
Current medicinal chemistry, Vol.25(38), pp.5177-5190
2018
DOI: 10.2174/0929867324666171010141416
PMID: 29032747
Abstract
Ebola virus has caused 26 outbreaks in 10 different countries since its identification in 1976, making it one of the deadliest emerging viral pathogens. The most recent outbreak in West Africa from 2014-16 was the deadliest yet and culminated in 11,310 deaths out of 28,616 confirmed cases. Currently, there are no FDA-approved therapeutics or vaccines to treat Ebola virus infections. The slow development of effective vaccines combined with the severity of past outbreaks emphasizes the need to accelerate research into understanding the virus lifecycle and the development of therapeutics for post exposure treatment. Here we present a summary of the major findings on the Ebola virus replication cycle and the therapeutic approaches explored to treat this devastating disease. The major focus of this review is on small molecule inhibitors.
Details
- Title: Subtitle
- Development of Potential Small Molecule Therapeutics for Treatment of Ebola Virus Disease
- Creators
- Adam Schafer - Department of Microbiology and Immunology, College of Medicine, University of Illinois at Chicago, Chicago, Illinois 60612, United StatesHan Cheng - Department of Microbiology and Immunology, College of Medicine, University of Illinois at Chicago, Chicago, Illinois 60612, United StatesCharles Lee - Department of Microbiology and Immunology, College of Medicine, University of Illinois at Chicago, Chicago, Illinois 60612, United StatesRuikun Du - Department of Microbiology and Immunology, College of Medicine, University of Illinois at Chicago, Chicago, Illinois 60612, United StatesJulianna Han - Department of Microbiology, The University of Chicago, Chicago, Illinois 60637, United StatesJasmine Perez - Department of Microbiology, The University of Chicago, Chicago, Illinois 60637, United StatesNorton Peet - Chicago Biosolutions Inc. Chicago, United StatesBalaji Manicassamy - Department of Microbiology, The University of Chicago, Chicago, Illinois 60637, United StatesLijun Rong - Department of Microbiology and Immunology, College of Medicine, University of Illinois at Chicago, Chicago, Illinois 60612, United States
- Resource Type
- Journal article
- Publication Details
- Current medicinal chemistry, Vol.25(38), pp.5177-5190
- DOI
- 10.2174/0929867324666171010141416
- PMID
- 29032747
- ISSN
- 0929-8673
- eISSN
- 1875-533X
- Language
- English
- Date published
- 2018
- Academic Unit
- Microbiology and Immunology
- Record Identifier
- 9984083267402771
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