Journal article
Development of Proanthocyanidin-Loaded Mesoporous Silica Nanoparticles for Improving Dental Adhesion
Molecular pharmaceutics, Vol.19(12), pp.4675-4684
11/09/2022
DOI: 10.1021/acs.molpharmaceut.2c00728
PMCID: PMC9727728
PMID: 36349888
Appears in UI Libraries Support Open Access
Abstract
Dentin biomodification is a promising approach to enhance dental tissue biomechanics and biostability for restorative and reparative therapies. One of the most active dentin tissue biomodifiers is proanthocyanidin (PAC)-rich natural extracts, which are used in the dental bonding procedure in combination with resin-based adhesives (RBAs). This study aimed to investigate the use of mesoporous silica nanoparticles (MSNs) for the sustained delivery of PACs for dentin biomodification as a novel drug-delivery system for dental applications. The effects of the incorporation of MSN functionalized with 3-aminopropyltriethoxysilane (APTES) and loaded with PAC into an experimental RBA were assessed by characterizing the material mechanical properties. In addition, the immediate and long-term bonding performance of an experimental resin-based primer (RBP) containing MSN-APTES loaded with PAC was also evaluated. For that, different formulations of RBA and RBP were prepared containing 20% w/v MSN-APTES loaded with PAC before or after functionalization (MSN-PAC-APTES and MSN-APTES-PAC, respectively). The incorporation of MSN-APTES-PAC did not negatively impact the degree of conversion or the overall mechanical properties of the RBA. However, adding MSN-PAC-APTES resulted in inferior mechanical properties of the experimental RBA. In the adhesion studies, APTES-functionalized MSN was successfully added to an experimental RBP for drug-delivery purposes without compromising the bond strength to the dentin or the failure mode. Interestingly, the sequence of surface functionalization with APTES resulted in differences in the bonding performance, with better long-term results for RBP containing MSN loaded with PAC after functionalization.
Details
- Title: Subtitle
- Development of Proanthocyanidin-Loaded Mesoporous Silica Nanoparticles for Improving Dental Adhesion
- Creators
- Ahmad Alkhazaleh - University of IowaSundes Elfagih - University of IowaLeela Raghava Jaidev Chakka - University of IowaSteven R Armstrong - University of IowaCarissa L Comnick - University of IowaFang Qian - University of IowaAliasger K Salem - University of IowaC Allan Guymon - University of IowaAmanda J Haes - University of IowaCristina M P Vidal
- Resource Type
- Journal article
- Publication Details
- Molecular pharmaceutics, Vol.19(12), pp.4675-4684
- DOI
- 10.1021/acs.molpharmaceut.2c00728
- PMID
- 36349888
- PMCID
- PMC9727728
- NLM abbreviation
- Mol Pharm
- ISSN
- 1543-8384
- eISSN
- 1543-8392
- Publisher
- American Chemical Society
- Grant note
- DOI: 10.13039/100004368, name: Colgate-Palmolive Company; name: College of Dentistry, University of Iowa
- Language
- English
- Date published
- 11/09/2022
- Academic Unit
- Preventive and Community Dentistry; Roy J. Carver Department of Biomedical Engineering; Dental Clinic Administration; Pharmaceutical Sciences and Experimental Therapeutics; Craniofacial Anomalies Research Center; Operative Dentistry; Family Dentistry; Chemistry; Dental Research; Chemical and Biochemical Engineering
- Record Identifier
- 9984314260102771
Metrics
5 Record Views